结直肠癌组织中PI3 K和Ezrin的表达及其意义

目的：通过检测结直肠癌组织中磷酯酰肌醇－3－激酶（PI3K）和埃兹蛋白（Ezrin）表达情况，探讨其表达特点及其临床意义。方法：采用免疫组化光波／微波（lightwave／microwave，LW／MW）－EliVisionTM法检测100例结直肠癌、30例正常黏膜中PI3K和Ezrin的表达情况，并分析二者与结直肠癌的关系及意义。结果：PI3K和Ezrin蛋白在正常黏膜及结直肠癌中表达阳性率差异均有统计学意义（P＜0．05）。而PI3K蛋白的高表达在结直肠癌TNM分期、浆膜浸润和淋巴结转移中有差异（P＜0．05），Ezrin蛋白与结直肠癌浸润深度、淋巴结转移密切相关（P＜0．05）；二者在结直肠癌组织中的表达无相关性（r＝0．06，P＞0．05）。结论：PI3K和Ezrin蛋白在结直肠癌的发生发展、侵袭、转移中起着重要作用，能为临床治疗结直肠癌及判断预后提供相关依据。

The expression and significance of PI3 K and Ezrin in colorectal carcinoma

Objective:To investigate the expression of PI3K and Ezrin in colorectal adenocarcinoma,and their fea-tures and clinical significance.Methods:The expression of PI3K and Ezrin was detected in 100 cases of colorectal ad-enocarcinoma and 30 cases of normal mucosa tissue by MW-EliVisionTM immunohistochemistry,and analyzed the re-lation between the expression and colorectal adenocarcinoma.Results:There was statistic signigicance in the expres-sion of PI3K and Ezrin in normal mucosa and colorectal adenocarcinoma(P<0.05).The high expression of PI3K was apparently correlated to TNMstage,serous membrane invasion and lymph node metastasis(P<0.05).The expression of PI3K was not related to the expression of Ezrin(r=0.06,P>0.05).Conclusion:PI3K and Ezrin might play im-portant roles in the development,invasion and metastasis of colorectal adenocarcinoma,which provided important im-formation in clinical therapy and predicting prognosis of colorectal adenocarcinoma.