High resolution SE-fMRI in humans at 3 and 7 T using a motor task |
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Authors: | Andreas Schäfer Wietske van der Zwaag Susan T Francis Kay E Head Penny A Gowland Richard W Bowtell |
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Affiliation: | (1) Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD, UK |
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Abstract: | Object The sensitivity of spin echo (SE) experiments to blood oxygenation level dependent (BOLD) contrast was explored in a study
of the same six subjects carried out at 3 and 7 T.
Materials and methods Multi-slice, single shot, spin echo, echo planar images with a voxel size of 1 × 1 × 3 mm3 were acquired at three different echo times, during execution of a simple motor task.
Results Significant activation was observed at all echo times at both field strengths. Analysis of the fractional signal change as
a function of echo time indicated that the change in relaxation rate, ΔR
2, at 7 T was −0.51 ± 0.14 s
−1, which was 1.3 times larger than the value found at 3 T. Measurements of the percentage signal change on activation and temporal
signal to noise ratio showed that there was an increase in the BOLD contrast to noise ratio (CNR) at 7 versus 3 T by a factor
of 1.9. There was no overlap of areas of significant activation in the SE data acquired at either field strength with the
site of large veins.
Conclusion SE-BOLD CNR in motor cortex was found to increase significantly at 7 T compared with 3 T. |
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Keywords: | BOLD High resolution High field fMRI Spin echo SE |
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