| 雌酚酮3-醚衍生物的合成与生理活性初探 |
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| 引用本文： | 李懿,翁玲玲.雌酚酮3-醚衍生物的合成与生理活性初探[J].华西药学杂志,2002,17(3):192-193,195. |
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| 作者姓名： | 李懿 翁玲玲 |
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| 作者单位： | 四川大学华西药学院,四川成都,610041 |
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| 摘 要： | 目的：合成雌激素3－醚化合物以观察雌激素活性，方法：以雌酚酮为原料，在3位与碱性侧相连，合成4个化合物，其中2个未见文献报道，并进行亲子宫和抗子宫和抗子宫活性测定，结果：经初步生理活性测定其雌激素活性明显小于母体化合物，结论：雌激素3－接上碱性侧链上对生理活性有影响。
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| 关 键 词： | 雌酚酮3－醚衍生物 合成 生理活性 碱性侧链 亲子宫活性 |
| 文章编号： | 1006-0103(2002)03-0192-03 |
SYNTHESIS OF ESTRONE 3-ETHERS DERIVATIVES AND PILOT STUDY OF BIOLOGICAL ACTIVITY |
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| LI Yi,WENG Ling-ling West China School of Pharmacy,Sichuan University,Chengdu ,China.SYNTHESIS OF ESTRONE 3-ETHERS DERIVATIVES AND PILOT STUDY OF BIOLOGICAL ACTIVITY[J].West China Journal of Pharmaceutical Sciences,2002,17(3):192-193,195. |
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| Authors: | LI Yi WENG Ling-ling West China School of Pharmacy Sichuan University Chengdu China |
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| Affiliation: | LI Yi,WENG Ling-ling West China School of Pharmacy,Sichuan University,Chengdu 610041,China |
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| Abstract: | OBJECTIVE To synthesize estrogenic compounds with 3-ethers structure to observe estrogenic activities. METHODS Combining estrone with basic side chain on 3-position, four compounds were synthesized, two of them have not been reported, and the activities of compounds were measured by their affinity to uterus. RESULTS Their estrogenic activities appeared obviously lower than that of the matrix compounds. CONCLUSION The estrogenic activities of estrone substituted on 3-position by basic side chains may be changed. |
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| Keywords: | Estradiol 3-ether Estrone Basic side chain Uterine affinity |
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