| Let-7家族在阿尔茨海默病发病机制中的作用 |
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| 引用本文： | 段冉冉,李燕飞,贾延劫.Let-7家族在阿尔茨海默病发病机制中的作用[J].国际生物医学工程杂志,2013(5):307-310. |
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| 作者姓名： | 段冉冉 李燕飞 贾延劫 |
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| 作者单位： | 郑州大学第一附属医院神经内科,河南省高等学校临床医学重点学科开放实验室,450000 |
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| 摘 要： | 阿尔茨海默病（AD）是一类病因未明的神经系统退行性疾病。近来研究发现，AD发生、发展可能与微小RNA（miRNA）的异常表达相关。Let-7家族作为第2个被发现的miRNA，参与调控细胞增殖、分化、凋亡、免疫应答、肿瘤发生及转移等多种生理病理过程。就Let-7家族在AD发病机制中的作用进行综述，旨在为探索AD新的生物标记及药物靶点提供参考。
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| 关 键 词： | 阿尔茨海默病 微小RNA Let-7 |
Role of Let-7 family in pathogenesis of Alzheimer disease |
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| DUAN Ran-ran,LI Yan-fei,JIA Yan-jie.Role of Let-7 family in pathogenesis of Alzheimer disease[J].International Journal of Biomedical Engineering,2013(5):307-310. |
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| Authors: | DUAN Ran-ran LI Yan-fei JIA Yan-jie |
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| Affiliation: | . Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Key-disciplines Laboratory Clinical- Medicine Henan, Zhengzhou 450000, China |
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| Abstract: | Alzheimer disease （AD） is a fatal neurodegenerative disorder, and the most common cause of dementia in the elderly. Accumulated evidences in AD research suggest that alterations in the microRNA （miRNA） network could contribute to risk for the disease. As the second discovered miRNA, Let-7 has an important effect on cell proliferation, differentiation, apoptosis, immune response, tumorigenesis, metastasis, and so on. We review in this article the role of Let-7 family in the pathogenesis of AD to provide a strong basis for future research aimed at understanding the potential contribution of miRNAs to AD pathophysiology. |
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| Keywords: | Alzheimer＇s disease miRNA Let-7 |
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