More frequent olive oil intake is associated with reduced platelet activation in obesity |
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| Affiliation: | 1. Department of Medicine, Leon H. Charney Division of Cardiology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA;2. NYU Center for the Prevention of Cardiovascular Disease, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA;3. Department of Surgery, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA;4. Department of Medicine, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA;1. Department of Clinical Laboratory, Zhenhai District Refining Hospital, Ningbo City, Zhejiang province, 315207, China;2. Departmeng of Internal Medicine,College of Clinical Medicine, QiLu Medical University, Zibocity, Shandong province, 255300, China;3. School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil;4. Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;5. Department of Hematology, Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania;6. Medical Surgical Nursing Department, Manipal College of Nursing, Manipal, Manipal Academy of Higher Education, Karnataka, India;7. Department of Endocrinology, Ankang Hospital of Traditional Chinese Medicine, Ankang City, Shaanxi Province, 725000, China;1. Endocrinology and Nutrition Department, Hospital Clínic de Barcelona, Spain;2. Endocrinology and Nutrition Department, Hospital Universitari Mútua de Terrassa, Spain;3. Obstetrics and Gynecology Department, Hospital Universitari Mútua de Terrassa, Spain;4. Fetal i+D Fetal Medicine Research Center, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, Spain;5. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;1. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China;2. Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China;3. Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China |
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| Abstract: | Background and aimsObesity is an independent risk factor for atherosclerotic cardiovascular disease (CVD), and platelet hyperactivation in obesity may contribute to this association. Olive oil consumption is associated with lower cardiovascular disease (CVD) risk in the general population. However, little is known for individuals with obesity. We investigated whether olive oil intake is associated with platelet activation in obesity.Methods and resultsWe assessed platelet activation (surface P-selectin expression) with and without thrombin exposure and diet composition in 63 patients with severe obesity.Among 63 subjects with obesity, the mean age was 32.2 ± 8.0 years and BMI 44.1 ± 8.5 kg/m2. Olive oil intake was stratified into <1 time/week (n = 21), 1–3 times/week (n = 18), ≥4 times/week (n = 24). Strata did not differ by age, BMI or platelet count. Unstimulated P-selectin expression did not differ by olive oil consumption. Subjects with more frequent olive oil intake exhibited lower P-selectin expression on submaximal thrombin exposure.ConclusionsMore frequent olive oil intake is associated with reduced thrombin-induced platelet activation in obesity. |
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| Keywords: | Platelet activation Obesity Olive oil P-selectin Cardiovascular disease |
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