HLA ANTIGEN DISTRIBUTION AND HAPLOTYPE SEGREGATION IN CHINESE PATIENTS WITH PSORIASIS

Tissue typing was performed on lymphocytes of 74 unrelated patients and 12 families with multiple affected siblings. HLA-B13, Aw19, B17 (Bw57), Cwl, DRl were found increased. The analysis of haplotype showed that one or two haplotype sharing among affected siblings occurred more frequently than expected (p<0.0001). The result of lods score for 4 families was l.940. These findings suggest that there may be at least one disease gene linked with MHC involved in this disease.