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| 小檗碱对颈动脉粥样硬化家兔NF-κB的影响 | |
| 引用本文： | 王建,何国厚,李承晏,刘勇.小檗碱对颈动脉粥样硬化家兔NF-κB的影响[J].武汉大学学报(医学版),2009,30(2). |
| 作者姓名： | 王建 何国厚 李承晏 刘勇 |
| 作者单位： | 1. 浙江省富阳市人民医院神经内科,浙江,富阳,311400 2. 郧阳医学院附属太和医院神经内科,湖北,十堰,442000 3. 武汉大学人民医院神经内科,湖北,武汉,430060 |
| 摘 要： | 目的:探讨小檗碱预防颈动脉粥样硬化形成的作用机制。方法:将24只雄性新西兰大白兔随机分成3组:正常组、颈动脉粥样硬化组(模型组)、小檗碱预防组(小檗碱组)。正常组给予正常饮食,模型组行高脂饲料喂养加颈动脉内膜空气干燥术建立颈动脉粥样硬化模型,小檗碱组在给予模型组相同处理的同时灌服小檗碱。术后4周麻醉处死,取颈动脉组织行HE染色、NF-κBP65免疫组织化学染色、RT-PCR法测NF-κBP65mRNA表达水平。结果:模型组血管病变以泡沫细胞为主,有动脉粥样斑块形成;小檗碱组血管主要显示内膜明显增厚,有少量泡沫细胞;小檗碱组NF-κBP65阳性细胞数密度高于正常组(P<0.05),明显低于模型组(P<0.05);RT-PCR半定量分析发现,小檗碱组NF-κBP65/β-actin扩增带吸光度值比值高于正常组(P<0.05),而明显低于模型组(P<0.05)。结论:小檗碱可能通过抑制NF-κB活性,降低组织中NF-κB含量,预防颈动脉粥样硬化形成。 |
| 关 键 词： | 小檗碱 颈动脉粥样硬化 核因子-κB |
Effect of Berberine on Nuclear Factor Kappa B in the Carotid Artery Atherosclerosis of Rabbit |
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| WANG Jian,HE Guohou,LI Chengyan,LIU Yong.Effect of Berberine on Nuclear Factor Kappa B in the Carotid Artery Atherosclerosis of Rabbit[J].Medical Journal of Wuhan University,2009,30(2). | |
| Authors: | WANG Jian HE Guohou LI Chengyan LIU Yong |
| Affiliation: | WANG Jian1,HE Guohou2,LI Chengyan3,LIU Yong2 1Dept.of Neurology,Renmin Hospital of Fuyang,Zhejiang 311400,China2Dept.of Neurology,Taihe Hospital of Yunyang University,Shiyan 442000,China3Dept.of Neurology,Renmin Hospital of Wuhan University,Wuhan 430060,China |
| Abstract: | Objective: To explore the mechanism of prevention of Berberine on the carotid artery atherosclerosis.Methods: Twenty-four New Zealand white rabbits were divided into normal group,carotid artery atherosclerosis(model group),and Berberine prevention group(Berberine group).The model group and Berberine group were fed with high cholesterol diet and the carotid artery atherosclerosis models were established by air-dry method,then the Berberine group were treated with Berberine respectively.After four weeks,all r... |
| Keywords: | Carotid Artery Atherosclerosis Berberine Nuclear Factor Kappa B |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
