| EB病毒Rta/IgG、EBNA1/IgA、VCA/IgA及EA/IgA抗体与鼻咽癌分期的关系 |
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| 引用本文： | 蔡永林,郑裕明,成积儒,王伟,张旖旎,王卫华,吴英松,杨淑君,钟伟铭,李军,莫永坤.EB病毒Rta/IgG、EBNA1/IgA、VCA/IgA及EA/IgA抗体与鼻咽癌分期的关系[J].南方医科大学学报,2010,30(3). |
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| 作者姓名： | 蔡永林 郑裕明 成积儒 王伟 张旖旎 王卫华 吴英松 杨淑君 钟伟铭 李军 莫永坤 |
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| 作者单位： | 南方医科大学生物技术学院;广西梧州市红十字会医院;南方医科大学第一临床医学院;湖北大学数计算学院;广州军区海军421医院特检科; |
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| 基金项目： | 广西壮族自治区卫生厅计划课题(Z2008472);;梧州市科技计划项目(200801063) |
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| 摘 要： | 目的探讨EB病毒Rta/IgG、EBNA1/IgA、VCA/IgA及EA/IgA抗体与鼻咽癌临床分期的关系。方法收集211例未经治疗的鼻咽癌患者的血清,用酶联免疫吸附法(ELISA)检测Rta/IgG、EBNA1/IgA抗体,用免疫酶法检测VCA/IgA及EA/IgA抗体,按92分期法进行分期,分别计算各T、N、M分期及临床分期的各抗体阳性率及抗体水平并进行统计学分析。结果鼻咽癌各T、N、M分期及临床分期组Rta/IgG抗体rA值均无统计学差异(P>0.05)。T1期的EBNA1/IgA抗体rA值明显低于其它T分期,N0期明显低于其它N分期,临床I期明显低于其它临床分期(P<0.05)。VCA/IgA、EA/IgA抗体滴度各N分期及临床分期间比较,差异有统计学意义(P<0.05)。结论EB病毒Rta/IgG抗体表达与鼻咽癌分期无关。EBNA1/IgA抗体在早期鼻咽癌表达水平相对较低。而VCA/IgA、EA/IgA抗体水平与颈部淋巴结转移程度相关,对于评估鼻咽癌临床分期有一定的参考价值。
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| 关 键 词： | 鼻咽癌 EB病毒 抗体 临床分期 |
Relationship between clinical stages of nasopharyngeal carcinoma and Epstein-Barr virus antibodies Rta/IgG, EBNA1/IgA, VCA/IgA and EA/IgA |
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| CAI Yong-lin,ZHENG Yu-ming,CHENG Ji-ru,WANG Wei,ZHANG Yi-ni,WANG Wei-hua,WU Ying-song,ZHONG Wei-ming,LI Jun,MO Yong-kun School of Biotechnology,First Medical Institute,Southern Medical University,Guangzhou ,China,Wuzhou Red Cross Hospital,Wuzhou.Relationship between clinical stages of nasopharyngeal carcinoma and Epstein-Barr virus antibodies Rta/IgG, EBNA1/IgA, VCA/IgA and EA/IgA[J].Journal of Southern Medical University,2010,30(3). |
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| Authors: | CAI Yong-lin ZHENG Yu-ming CHENG Ji-ru WANG Wei ZHANG Yi-ni WANG Wei-hua WU Ying-song ZHONG Wei-ming LI Jun MO Yong-kun School of Biotechnology First Medical Institute Southern Medical University Guangzhou China Wuzhou Red Cross Hospital Wuzhou |
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| Affiliation: | CAI Yong-lin1,2,ZHENG Yu-ming2,CHENG Ji-ru2,WANG Wei3,ZHANG Yi-ni3,WANG Wei-hua4,WU Ying-song1,ZHONG Wei-ming2,LI Jun2,MO Yong-kun2 1School of Biotechnology,3First Medical Institute,Southern Medical University,Guangzhou 510515,China,2Wuzhou Red Cross Hospital,Wuzhou 543002,4Institute of Mathematics , Computer Science,Hubei University,Wuhan 430062,5Department of Special Diagnosis,421 Hospital of PLA,Guangzhou 510310 |
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| Abstract: | Objective To evaluate the relationship between the clinical stages of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) antibodies Rta/IgG, EBNA1/IgA, VCA/IgA and EA/IgA. Methods Serum samples obtained from 211 untreated patients with NPC categorized by the project of 92' stage were examined for the presence of the EBV antibodies Rta/IgG and EBNA1/IgA by enzyme-linked immnunosorbent assay (ELISA) and for VCA/IgA and EA/IgA by immunoenzymatic assay. The positive rates and antibody levels in the NPC... |
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| Keywords: | nasopharyngeal carcinoma Epstein-Barr virus antibody clinical stage |
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