|
|||||
|
|
| RyR2相关心脏性猝死的研究进展 | |
| 引用本文： | 邢景军,段祎杰,王昊,丁杨,杨怡,李上勋,朱少华,周亦武.RyR2相关心脏性猝死的研究进展[J].中国法医学杂志,2013,28(3):226-229. |
| 作者姓名： | 邢景军 段祎杰 王昊 丁杨 杨怡 李上勋 朱少华 周亦武 |
| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北武汉,430030 2. 华中科技大学同济医学院法医学系,湖北武汉430030;重庆市公安局,重庆400021 3. 华中科技大学同济医学院法医学系,湖北武汉430030;湖北省公安厅,湖北武汉430070 |
| 基金项目： | 国家自然科学基金面上项目 |
| 摘 要： | 雷诺定受体2(ryanodine receptor 2,RyR2)是心肌细胞肌浆网上主要的钙释放通道,主要参与心肌的兴奋收缩耦联过程,其基因突变及调控异常可导致心肌舒张期钙漏引起心律失常,甚至猝死。本文重点综述RyR2基因突变及调控异常引起心脏性猝死的机制,并对以后的研究提出建议,旨在为心脏性猝死的法医学诊断提供一种新的思路。 |
| 关 键 词： | 法医病理学 雷诺定受体2 心脏性猝死 法医学诊断 研究进展 |
Research progression of RyR2-related sudden cardiac death |
|
| Xing Jingjun,Duan Yijie,Wang Hao,Ding Yang,Yang Yi,Li Shangxun,Zhu Shaohua,Zhou Yiwu.Research progression of RyR2-related sudden cardiac death[J].Chinese Journal of Forensic Medicine,2013,28(3):226-229. | |
| Authors: | Xing Jingjun Duan Yijie Wang Hao Ding Yang Yang Yi Li Shangxun Zhu Shaohua Zhou Yiwu |
| Affiliation: | 1/ 1.Department of Forensic medicine,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China;2.Chongqing Municipal Public Security Bureau,Chongqing 400021,China;3.Hubei Provincial Public Security Department,Wuhan 430070,China) |
| Abstract: | Ryanodine receptor 2(RyR2) is a primary calcium release channel on sarcoplasmic reticulum of cardiocytes to provide the major source of calcium required for cardiac muscle excitation contraction(EC) coupling.Arrhythmia,or sudden death may happen due to the calcium leakage that caused by the gene mutation and dysregulation of RyR2.In this paper,mechanism of sudden cardiac death caused by gene mutation and abnormal regulation of RyR2 was reviewed.Moreover,some suggestions were presented for further research to provide a new thought for the diagnosis of sudden cardiac death in forensic science. |
| Keywords: | forensic pathology ryanodine receptor 2 sudden cardiac death forensic diagnosis research progression |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
