| 进展期胃癌患者术后腹腔持续温热灌注化疗联合静脉化疗的疗效观察 |
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| 引用本文： | 张峰,刘国平,刘畅,刘晓军.进展期胃癌患者术后腹腔持续温热灌注化疗联合静脉化疗的疗效观察[J].中国临床医学,2011,18(3):338-340. |
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| 作者姓名： | 张峰 刘国平 刘畅 刘晓军 |
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| 作者单位： | 1. 复旦大学附属金山医院急诊科,上海,200540
2. 上海第二军医大学,上海,200433 |
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| 摘 要： | 目的：观察进展期胃癌术后行腹腔持续温热灌注联合全身静脉化疗的临床疗效。方法：135例进展期胃癌术后患者随机分为治疗组和对照组。治疗组67例,行腹腔持续温热灌注联合全身静脉化疗4次,之后行常规静脉化疗;对照组68例,行常规静脉化疗12次;2组常规化疗均采用FOLFOX6方案,并均于术后4周开始常规化疗。结果：（1）治疗组1年、3年、5年生存率分别为95.38%、78.63%和58.47%;对照组分别为93.21%、67.95%和41.81%。2组1年生存率差异无统计学意义（P〉0.05）,3年、5年生存率差异有统计学意义（P〈0.05）;（2）治疗组卡氏评分法（KPS）评分升高率为59.70%,对照组为42.65%,2组KPS升高率比较差异有统计学意义（P〈0.05）;（3）治疗组腹腔局部复发率显著低于对照组（14.92%比30.88%,P〈0.05）,而远处转移率2组差异无统计学意义（32.84%比35.29%,P〉0.05）;（4）治疗不良反应主要为消化系统反应与造血系统抑制,但无一例因化疗不良反应而影响治疗。结论：腹腔持续温热灌注联合全身静脉化疗可降低化疗不良反应,延缓病情发展、改善生活质量,延长进展期胃癌术后患者的生存期。
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| 关 键 词： | 进展期胃癌 腹腔持续温热灌注化疗 静脉化疗 |
Postoperative Intraperitoneal Hyperthermia Chemoperfusion Combined with Intravenous Chemotherapy for Advanced Gastric Cancer Patients |
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| ZHANG Feng,LIU Guoping,LIU Chang,LIU Xiaojun.Postoperative Intraperitoneal Hyperthermia Chemoperfusion Combined with Intravenous Chemotherapy for Advanced Gastric Cancer Patients[J].Chinese Journal Of Clinical Medicine,2011,18(3):338-340. |
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| Authors: | ZHANG Feng LIU Guoping LIU Chang LIU Xiaojun |
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| Affiliation: | ZHANG Feng1 LIU Guoping1 LIU Chang1 LIU Xiaojun2 1.Department of Emergency,Jinshan Hospital,Fudan University,Shanghai 200540,China,2.Second Military Medical University,Shanghai 200433 |
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| Abstract: | Objective:To evaluate the efficacy of postoperative intraperitoneal hyperthermia chemo perfusion(IHCP)combined with intravenous chemotherapy for advanced gastric cancer.Methods:A total of 135 advanced gastric cancer patients were postoperatively randomized into two groups;67 patients in treatment group who received IHCP combined with intravenous chemotherapy for four times and 68 patients in control group who received intravenous chemotherapy only for twelve times;All patients in the two groups received the... |
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| Keywords: | Advanced gastric cancer Intraperitoneal hyperthermia chemoperfusion(IHCP) Intravenous chemotherapy |
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