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| 阿苯达唑自微乳化释药系统大鼠体内药代动力学的研究 | |
| 引用本文： | 魏丽红,张永军,陈卫军,张丽娜,朱雅婷,李雪芹.阿苯达唑自微乳化释药系统大鼠体内药代动力学的研究[J].农垦医学,2011,33(2):125-129. |
| 作者姓名： | 魏丽红 张永军 陈卫军 张丽娜 朱雅婷 李雪芹 |
| 作者单位： | 1. 石河子大学药学院,新疆石河子,832002 2. 石河子大学医学院第一附属医院,新疆石河子,832008;华中科技大学同济医学院药学院,武汉,430030 3. 石河子大学医学院第一附属医院,新疆石河子,832008 |
| 摘 要： | 目的：研究阿苯达唑自微乳化释药系统在大鼠体内的药代动力学。方法：通过高效液相色谱法,以阿苯达唑原料药和市售片剂做对照,对高低剂量口服阿苯达唑自微乳浓缩液进行大鼠体内相对生物利用度研究,利用DAS药动学软件对血药浓度数据进行处理。结果：血药浓度测定的方回收率均大于70%,日内、日间精密度良好;大鼠分别以38 mg/kg的剂量灌胃给予原料药、片剂和ABZ-SMEDDS后,大鼠体内血药浓度-时间曲线结果表明：SMEDDS的AUC分别是市售片剂和原料药的2倍和3倍多,且药时曲线的形状发生一定的改变。结论：自微乳系统可显著提高ABZ口服生物利用度。 |
| 关 键 词： | 阿苯达唑 自微乳化给药系统 药代动力学 |
Pharmacokinetics of self-microemulsifyingdrug deliverysystem albendazole in rat |
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| WEI Li-hong,ZHANG Yong-jun,CHEN Wei-jun,ZHANG Li-na,ZHU Ya-ting,LI Xue-qing.Pharmacokinetics of self-microemulsifyingdrug deliverysystem albendazole in rat[J].Agricultural Reclamation Medicine,2011,33(2):125-129. | |
| Authors: | WEI Li-hong ZHANG Yong-jun CHEN Wei-jun ZHANG Li-na ZHU Ya-ting LI Xue-qing |
| Affiliation: | WEI Li-hong1,ZHANG Yong-jun2,3,CHEN Wei-jun2,ZHANG Li-na1,ZHU Ya-ting1,LI Xue-qing1(1.Pharmacy School of Shihezi University,Xinjiang Shihezi,832002,2.The First Affiliated Hospital of Shihezi University School of Medicine,832008,3.Tongji School of Pharmacy,Huazhong University of Science and Technology,Wuhan,430030) |
| Abstract: | Objective:The HPLC method was developed for the determination of Albendazole in mouse Plasma.pharmacokinetics of Albendazole Microemulsion in mouse after oral administration were investigated. Methods:The concentration of drug and metabolites in plasma was determined by HPLC,The rats plasma after double doses oral administration of ABZ-SMEDDS and conventional tablet,pharmaceutical product concentration and its metabolites were determined by HPLC.Compared with conventional tablet and pharmaceutical product,t... |
| Keywords: | Albendazole self-microemulsifyingdrug delivery system pharmacokinetic |
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