降钙素原及白细胞介素-6在急性胰腺炎患者早期感染诊断及预后的意义

目的 探讨降钙素原(PCT)及白细胞介素-6(IL-6)在急性胰腺炎(AP)患者早期感染诊断及预后的意义.方法 对70例确诊AP患者分别抽取住院第1、3、5、7天血标本,随机抽取40例健康体检者血标本,应用酶联免疫双抗体夹心法检测血清IL-6水平,双抗夹心免疫法检测PCT水平.结果 重症AP (SAP)组、全身炎症反应综合征(SIRS)组及胆源性AP(AGP)组患者住院第1天PCT的阳性率分别为88.9％、82.8％及61.4％,高于轻症AP(MAP)组、非SIRS组及非AGP组的19.2％、14.6％及15.4％ (P＜0.01),并在2d后随着病情好转迅速下降；SAP、SIRS组在入院后各时间段血清IL-6含量均高于MAP组、非SIRS组(P＜0.01),而AGP组与非AGP组IL-6含量在各时间段差异均无统计学意义.结论 PCT、IL-6检测可早期判断AP患者感染严重程度,且PCT敏感度更高；PCT对AP患者的预后有一定意义.

Value of procalcitonin and interleukin-6 in diagnosis of early infections and prognosis of patients with acute pancreatitis

OBJECTIVE To study the value of procalcitonin and interleukin-6 in diagnosis of early infections and prognosis of the patients with acute pancreatitis.METHODS The blood samples were respectively extracted from 70 patients with diagnosed acute pancreatitis on the 1st,3rd,5th,and 7th day since the admission.and the blood samples of 40 healthy people were obtained,the serum IL-6 level was determined by ELISA,and the PCT level was determined by ILMA.RESULTS The positive rates of PCT in the SAP,SIRS and AGP group were 88.9%,82.8%,and 61.4%,significantly higher than 19.2%,14.6%,and 15.4% in the MAP,non-SIRS and non-AGP group(P<0.01);the positive rate of PCT were significantly decreased as the condition improved;the levels of IL-6 in the SAP and SIRS group were significantly higher than those in the MAP and non-SIRS group(P<0.01);the difference in the level of IL-6 between the AGP group and non-AGP group was not statistically significant.CONCLUSION PCT is more sensitive than IL-6 in the early judgment of the severity of the infections in acute pancreatitis patients;PCT is valuable for prognosis of patients with acute pancreatitis in a certain degree.