| 玻璃体内注射康柏西普治疗早产儿视网膜病变的血管化过程 |
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| 引用本文： | 傅征,熊薇薇,尹雪,洪志斌,李秀婷,魏熙翔,方伟芳,陈亚娟,林经纬,朱彦晖,朱益华,杨晖.玻璃体内注射康柏西普治疗早产儿视网膜病变的血管化过程[J].国际眼科杂志,2023,23(3):363-368. |
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| 作者姓名： | 傅征 熊薇薇 尹雪 洪志斌 李秀婷 魏熙翔 方伟芳 陈亚娟 林经纬 朱彦晖 朱益华 杨晖 |
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| 作者单位： | 中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科,中国福建省福州市,福建医科大学附属第一医院眼科,中国福建省厦门市,复旦大学附属儿科医院厦门医院眼科 |
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| 基金项目： | 2018厦门市医疗卫生指导项目(No.3502Z20189046); 2020厦门市医疗卫生指导项目(No.3502Z20209224) |
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| 摘 要： | 目的：评价玻璃体内注射康柏西普在治疗I型(阈值期和阈值前期)和A-ROP(急进性ROP)的早产儿视网膜病变(ROP)的一系列病例中引起的视网膜血管化过程。方法：回顾性研究2017-07/2020-03在厦门市儿童医院眼科通过玻璃体腔注射康柏西普(IVC)治疗的ROP患者34例67眼。再活化是指急性期特征的复发，发生在疾病的任何阶段，无论是否存在其他疾病。结果：患儿34例的平均胎龄为28.82±2.32wk。平均出生体质量为1155.18±398.22g。19例37眼的病变区域为Ⅰ区。10例20眼的病变位于Ⅱ区，5例10眼的病变位于Ⅱ区后部。一次IVC治疗的ROP患儿疾病控制总有效率为73.1%(49/67)，且Ⅱ区血管化均完成。患者在Ⅲ区的血管化完成率出现差异。在接受过一次治疗且未再复发的患者中，Ⅰ型ROP血管化时间平均为9.11±2.49wk，A-ROP为13.40±4.04wk。A-ROP的血管化完成时间明显比Ⅰ型ROP的时间长，且结果有统计学差异。结论：IVC治疗后的病变为Ⅱ区的患儿均具有较高的血管完成率。
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| 关 键 词： | 康柏西普 早产儿视网膜病变 血管化 |
| 收稿时间： | 2022/2/21 0:00:00 |
| 修稿时间： | 2023/1/19 0:00:00 |
Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity |
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| Zheng Fu,Wei-Wei Xiong,Xue Yin,Zhi-Bin Hong,Xiu-Ting Li,Xi-Xiang Wei,Wei-Fang Fang,Ya-Juan Chen,Jing-Wei Lin,Yan-Hui Zhu,Yi-Hua Zhu and Hui Yang.Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity[J].International Journal of Ophthalmology,2023,23(3):363-368. |
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| Authors: | Zheng Fu Wei-Wei Xiong Xue Yin Zhi-Bin Hong Xiu-Ting Li Xi-Xiang Wei Wei-Fang Fang Ya-Juan Chen Jing-Wei Lin Yan-Hui Zhu Yi-Hua Zhu and Hui Yang |
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| Affiliation: | Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China,Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China and Department of Ophthalmology, Children''s Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, China |
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| Abstract: | |
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| Keywords: | Conbercept retinopathy of prematurity vascularization |
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