卡培他滨联合方案治疗老年晚期结直肠癌的临床研究

目的 评价卡培他滨联合方案治疗老年晚期结直肠癌的疗效与不良反应.方法 77例老年晚期结直肠癌患者随机分组,卡培他滨联合组(36例)接受奥沙利铂(L-OHP)加卡培他滨方案化疗,OLF组(41例)接受L-OHP加氟尿嘧啶,亚叶酸钙(FU/CF)方案化疗.观察对比其疗效与不良反应.结果 卡培他滨联合组的有效率为41.67%,肿瘤控制率(临床受益率)为77.78%,中位肿瘤进展时间为7.9个月.OLF组的有效率为39.02%,肿瘤控制率为75.61%,中位肿瘤进展时间为7.2个月.两组有效率比较差异无统计学意义(P＞0.05).不良反应:两组均无严重的化疗相关不良反应,两组患者骨髓抑制、消化道反应、脱发、皮疹、肝肾功能损害、神经毒性的发生率比较差异均无统计学意义(P均＞0.05),卡培他滨联合组手足综合征的发生率较OLF组明显升高(P＜0.05).结论 对老年晚期结直肠癌患者,卡培他滨联合方案与OLF方案疗效相仿,不良反应均可耐受,卡培他滨口服给药缩短了住院时间,提高了老年患者的生活质量,卡培他滨联合方案不失为一种老年晚期结直肠癌患者一线治疗方案的较佳选择.

Clinical study of capecitabine combined chemotherapy regimen in treatment of advanced colorectal cancer in senile patients

Objective To evalume the efficacy and side effect of capecitabine combined chemotherapy regimen in treatment of advanced cohrectal cancer in senile patients.Methods Seventy-seven cases senile patients with advanced colorectal cancer were randomly divided in two groups.capecitabine combination group (36 cases) received oxaliplatin (L-OHP)+ eapecitabine regimen, OLF group (41 cases) received L-OHP+ FU/CF regimen. The efficacy and side effect were observed and compared between two groups.Results eapecitabine combination group:the cfficiency rate was 41.67%,the tumor control rate was 77.78%.meso-tumor to progression was 7.9 months.OLF group:the efficiency rate was 39.02%,the tumor control rate was 75.61%,meso-tumor to progression was 7.2 months.The effectiveness in two groups had no significant difference (P＞005).There was no serious chemotherapy related side effect in two groups.The rates of marrow inhibition,nausea,vomiting,diarrhea,alopecia,rash,the lesion of liver and renal function and peripheral neuritis were similar in two groups.The rate of hand-foot syndrome was apparently higher in capecitabine combination group compared with OLF group (P＜0.05).Conclusions For senile advanced colorectal cancer patienrs,the treatment efficiency is similar between capecitabiae combination regimen and OLF regimen,the side effect is all tolerated in two regimens.capecitabine combination regimen is oral adminisuered and decurates hospitnlization time and improved the life quality of senile patients.capecitabine combination regimen is a suitable fast-line regimen for senile advanced colorectal cancer pafients.