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| 海嘧啶对小鼠肝脏脂质过氧化反应的影响 | |
| 引用本文： | 王志举,乔鹏,刘素芳,赵文超,董子明,季宇彬.海嘧啶对小鼠肝脏脂质过氧化反应的影响[J].中国实用神经疾病杂志,2006,9(5):25-26. |
| 作者姓名： | 王志举 乔鹏 刘素芳 赵文超 董子明 季宇彬 |
| 作者单位： | 1. 郑州大学基础医学院生理学教研室,郑州,450052 2. 郑州大学基础医学院病理生理学教研室,郑州,450052 3. 哈尔滨商业大学药学院,哈尔滨,150076 |
| 摘 要： | 目的观察海嘧啶对荷瘤小鼠肝脏脂质过氧化反应的影响。方法S180（骨肉瘤）及EAC（艾氏腹水癌）荷瘤小鼠随机分为三组：正常组、阴性对照组和海嘧啶治疗组。海嘧啶治疗组：小鼠接瘤后24h后腹腔注射药物，50mg／kg。连续给药7d。阴性对照组给相同体积的生理盐水。分别测定肝组织的LPO、GSH—PX和SOD的含量。结果荷瘤小鼠肝中LPO含量升高，而GSH—PX和SOD均含量降低；海嘧啶治疗组荷瘤小鼠肝中GSH—PX和SOD的活性升高，LPO的含量降低。结论海嘧啶的抗肿瘤机制可能与它能提高抗氧化酶的活性，清除过多自由基有一定关系。 |
| 关 键 词： | 海嘧啶 脂质过氧化物 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
| 文章编号： | 1673-5110（2006）05-0025-02 |
| 收稿时间： | 2006-06-01 |
| 修稿时间： | 2006年6月1日 |
Effect of the sea pyrimidine on lipid peroxidation of liver in tumor bearing mice |
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| Wang Zhiju, Qiao Peng ,Liu Sufang, et al.Effect of the sea pyrimidine on lipid peroxidation of liver in tumor bearing mice[J].Chinese Journal of Practical Neruous Diseases,2006,9(5):25-26. | |
| Authors: | Wang Zhiju Qiao Peng Liu Sufang |
| Abstract: | Objective To observe the effect of the sea pyrimidine on lipid peroxidation of liver in tumor bearing mice.Methods Mice were divided into 3 groups: normal group,treat ment group and control group.Mice of treat group were transplanted with tumor cells of S180 and EAC,and treated with Sea pyrimidine for 7 days(50mg/kg,ip).Mice of control group were transplanted with tumor cells of S180 and EAC,and treated with 0.9% NaCl for 7 days.And LPO,GSH-PX and SOD were examined respectively.Results Sea primidine can reduce the levels of LPO of liver tumor bearing mice and increase the levels of SOD and GSH-PX.Conclusion The antitumor pharmacologic mechanism of the sea pyrimidine is related to it's increasing the levels of SOD and GSH-PX,and to it's inhibition the action of lipid peroxidation. |
| Keywords: | Sea pyrimidine Lipid peroxidation LPO SOD GSH-PX |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
