| 维生素A缺乏对大鼠细胞免疫功能的影响 |
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| 引用本文： | 马轶凡,陈荣华.维生素A缺乏对大鼠细胞免疫功能的影响[J].营养学报,1998,20(2):142-146. |
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| 作者姓名： | 马轶凡 陈荣华 |
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| 作者单位： | 南京医科大学儿科系 |
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| 摘 要： | 方法：初断乳ＳＤ大鼠２４只，均分为严重ＶＡ缺乏（Ａ）、轻度ＶＡ缺乏（Ｂ）和正常对照（Ｃ）三组，饲含ＶＡ０、４００、６００ＩＵ／ｋｇ饲料８周，测定大鼠外周血淋巴细胞转化、Ｔ细胞亚群及单个核细胞ＩＬ－２，ＴＮＦ－α变化。结果：重度ＶＡ缺乏会导致大鼠胸腺和脾脏的萎缩，ＣＤ３、ＣＤ４亚群减少，ＣＤ４／ＣＤ８下降，淋巴细胞转化受抑，单个核细胞分泌ＩＬ－２、ＴＮＦ－α明显减少；轻度ＶＡ缺乏时，虽无明显临床表现，但ＣＤ４、ＣＤ４／ＣＤ８有所降低，ＩＬ－２及ＴＮＦ－α亦分泌减少。结论：轻度ＶＡ缺乏和严重ＶＡ缺乏均会使细胞免疫功能受损，需引起重视
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| 关 键 词： | 维生素A 细胞免疫 |
THE EFFECTS OF VITAMIN A DEFICIENCY ON CELL MEDIATED IMMUNITY IN RATS |
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| Ma Yifan,Chen Ronghua,Deng Jingyin.THE EFFECTS OF VITAMIN A DEFICIENCY ON CELL MEDIATED IMMUNITY IN RATS[J].Acta Nutrimenta Sinica,1998,20(2):142-146. |
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| Authors: | Ma Yifan Chen Ronghua Deng Jingyin |
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| Abstract: | The effects of different level of vitamin A deficiency (VAD) on cell mediated immunity were studied in rats.It showed that serious VAD resulted marked atrophy of immune organs and abnormal T cell subsets and inhibited the proliferative response to ConA and productions of IL 2、TNF α.Although no clinical symptom was observed in marginal VAD group,the distribution of T cell subsets was abnormal and productions of IL 2、TNF α decreased.It was concluded that cell mediated immunity was impaired both in marginal and serious vitamin A deficient rats. |
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| Keywords: | vitamin A deficiency cell mediated immunity |
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