上海地区实验动物病原体感染指数分析

目的 为了更直观的了解实验动物质量控制情况，本文引“感染指数”这一评估指标。探索测算感染指数的最佳方法，以便更加科学的反映实验动物的感染状况。方法 感染指数，也称感染度，它是对实验动物质量监测的定性指标。通过加工汇总实验动物的病原体感染率，综合反映某一特定实验动物群体的病原体感染状态或趋势的一种指标。结果 总体上，小鼠病原体感染指数呈逐年下降的趋势，而大鼠的病原体感染指数则逐年上升。分别比较各类病原体感染指数发现，小鼠中寄生虫感染指数最高，而大鼠中细菌感染指数最高。结论 感染指数分析揭示了实验动物质量的基本状况，需要加强对小鼠寄生虫的监测，而大鼠的细菌检测需要投入更多关注。小鼠病原体感染情况得到控制，大鼠各类病原体的控制情况均逐年趋于严重。

Analysis of laboratory animal pathogen infection indexes in Shanghai area

Objective To more intuitively understand the quality control for laboratory animals and further achieving a more scientific and reasonable management of experimental animal, the infection index as evaluation criteria was introduced. Then the best way to calculate infection index was explored in order to more scientifically reflect the infection status of laboratory animal. Methods Infection index, also called the degree of infection, is a qualitative indicator of monitoring laboratory animal quality. After arranging, analyzing, processing and gathering the data from laboratory animal quality monitoring, the index reflects synthetically the pathogen infection status or trend of a particularly investigated experimental animal population or the development of certain experimental animals. Results In general, the pathogen infection index of mice decreased year by year; While the pathogen infection index of rat roughly increased year by year. In comparing infection index by different pathogens, the parasite infection index of mice was found to be higher than bacteria infection index and virus ones, while the bacteria infection index of rats was higher than parasite infection index and virus ones. Conclusions The infection index model intuitively reflected the quality control status of laboratory animals. And the analysis also reveals that the parasite monitoring of the mice and the bacteria detection of rat need reinforcement. In addition, the index of infection revealed that the pathogen infection of mice was well under control, while that of rat tended to be more serious year by year.