| 高血压病患者血小板Na~ -H~ 交换与Ca~(2 )内流、Ca~(2 )结合力的关系 |
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| 引用本文： | 祝之明,宋克群,周正友,牟永芳,刘光耀.高血压病患者血小板Na~ -H~ 交换与Ca~(2 )内流、Ca~(2 )结合力的关系[J].中国循环杂志,1993(8). |
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| 作者姓名： | 祝之明 宋克群 周正友 牟永芳 刘光耀 |
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| 作者单位： | 第三军医大学第三附属医院高血压研究室
(祝之明，宋克群，周正友，牟永芳)，第三军医大学第三附属医院高血压研究室(刘光耀) |
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| 摘 要： | 细胞内pH对血管平滑肌结构和功能有重要影响,本文通过观察高血压病患者血小板Na~ -H~ 交换活性、血小板Ca~(2 )内流和Ca~(2 )结合力等指标,探讨了细胞Na~ -H~ 交换活性和Ca~(2 )代谢与血压间的关系。
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| 关 键 词： | 高血压 血小板 Na~ -H~ 交换 钙内流 钙结合力 |
PLATELET Na~ -H~ EXCHANGE, Ca~(2 ) INFLUX AND MEMBRANE BOUND Ca~(2 ) IN HYPERTENSIVES |
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| Zhu Zhi-Ming,Song Ke-Qun,Zhou Zheng You,et al..PLATELET Na~ -H~ EXCHANGE, Ca~(2 ) INFLUX AND MEMBRANE BOUND Ca~(2 ) IN HYPERTENSIVES[J].Chinese Circulation Journal,1993(8). |
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| Authors: | Zhu Zhi-Ming Song Ke-Qun Zhou Zheng You |
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| Affiliation: | Zhu Zhi-Ming,Song Ke-Qun,Zhou Zheng You,et al. Hypertension Laboratory,Third Hospital,Third Military Medical College,Chongqing |
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| Abstract: | Intracelluar pH plays an important role in the structure and function of vascular smooth muscle cells. Na~ -H~ exchange, Ca~(2 ) influx and membrane bound Ca~(2 ) (Ca_b~(2 )) of platelet were measured in hypertensives (HT). We found that platelets of HT had higher Na~ -H~ exchange, Ca~(2 ) influx and Ca_b~(2 ) than those of normal controls. And the activity of Na~ -H~ exchange showed significantly positive correlation with blood pressure, Ca~(2 ) influx and Ca_b~(2 ) in HT. It suggests that hyperactivity of cellular Na~ -H~ exchange is associated with high peripheral resistance, whieh is involved in the disturbance of cellular calcium metabolism. |
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| Keywords: | Hypertension Na~ -H~ exchange Ca~(2 ) influx Membrane bound Ca~(2 ) Ptatelet |
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