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| p14ARF与皮肤恶性肿瘤的关系 | |
| 引用本文： | 郑博文,谢余澄,杨娜,邹勇莉,阮光洪.p14ARF与皮肤恶性肿瘤的关系[J].国际皮肤性病学杂志,2011,37(5). |
| 作者姓名： | 郑博文 谢余澄 杨娜 邹勇莉 阮光洪 |
| 作者单位： | 1. 云南省第二人民医院皮肤科,昆明,650033 2. 云南省第二人民医院病理科,昆明,650033 3. 昆明医学院第一附属医院皮肤科 |
| 摘 要： | p14ARF是近年来发现的抑癌基因之一，其通过p53、Rb及促分裂原活化蛋白激酶这3条相互独立的通道在细胞周期的调控中发挥作用。研究表明，p14ARF在包括皮肤恶性肿瘤在内的多种恶性肿瘤中的表达均有显著下调。p14ARF的功能失活的机制主要包括基因的甲基化、基因缺失和突变，其中以甲基化最为常见。目前科学家将p14ARF作为治疗恶性肿瘤的靶向之一进行了有益的探索，并取得了初步成果。 |
| 关 键 词： | 肿瘤抑制蛋白质p14ARF 皮肤肿瘤 |
p14ARF and cutaneous malignancies |
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| ZHENG Bo-wen,XIE Yu-cheng,YANG Na,ZOU Yong-li,RUAN Guang-hong.p14ARF and cutaneous malignancies[J].International Journal of Dermatology and Venereology,2011,37(5). | |
| Authors: | ZHENG Bo-wen XIE Yu-cheng YANG Na ZOU Yong-li RUAN Guang-hong |
| Abstract: | P14ARF is a newly discovered tumor-suppressor gene that regulates cell cycle through three independent pathways, i.e., p53, Rb and mitogen-activated protein kinase (MAPK). It has been revealed that the expression of p14ARF is downregulated in many malignant tumors including cutaneous malignancies. p14ARF may be inactivated by gene methylation, deletion and mutation, of which, methylation is the most common. At present, scientists are attempting to use p14ARF as a target to treat malignant tumors and have made initial progress. |
| Keywords: | Tumor suppressor protein p14ARF Skin neoplasms |
| 本文献已被 万方数据 等数据库收录！ | |
