| 茵陈蒿汤醇提物对机体抗氧化能力影响 |
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| 引用本文： | 洪敏,朱荃,李晓冬,孙小玉.茵陈蒿汤醇提物对机体抗氧化能力影响[J].时珍国医国药,1999,10(11):806-807. |
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| 作者姓名： | 洪敏 朱荃 李晓冬 孙小玉 |
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| 作者单位： | 南京中医药大学,南京,210029 |
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| 摘 要： | 为探讨茵陈蒿汤醇提物的保肝作用与机体抗氧化能力的关系，实验观察茵陈蒿汤醇提物在Ｄ─氨基半乳糖＋脂多糖（Ｄ—ＧａｌＮ＋ＬＰＳ）和卡介苗＋脂多糖（ＢＣＧ＋ＬＰＳ）模型中对ＡＬＴ、ＧＳＴ、ＬＰＯ、ＳＯＤ及ＧＳＨ的影响。结果：茵陈蒿汤醇提物ｉｇ．６ｇ／ｋｇ和９ｇ／ｋｇ明显降低Ｄ—ＣａｌＮ＋ＬＰＳ肝损伤小鼠血清谷丙转氨酶（ＡＬＴ）活性，降低谷胱甘肽─Ｓ─转移酶（ＧＳＴ）水平，减少肝匀浆中脂质过氧化物（ＬＰＯ）含量，对超氧化物歧化酶（ＳＯＤ）活性无明显影响；４ｇ／ｋｇ，６ｇ／ｋｓ和９ｇ／ｋｓ显著降低ＢＣＧ＋ＬＰＳ免疫性肝损伤小鼠血清ＡＬＴ水平，６ｇ／ｋｇ和９ｇ／ｋｇ增加肝匀浆还原型谷胱甘肽（ＧＳＨ）含量。表明茵陈蒿汤醇提物经口给药能明显提高小鼠抗自由基损伤的能力，为其保肝作用的机理之一。
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| 关 键 词： | 茵陈蒿汤醇提物 BCG＋LPS免疫性肝损伤 D—GalN＋LPS肝损伤 |
Antilipoperoxidation Activity of Alcohol Extract of Capillaris D ecoction |
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| Hong Min, Zhu Quan, Li Xiaodong,at alNaming University of TCM.Antilipoperoxidation Activity of Alcohol Extract of Capillaris D ecoction[J].Lishizhen Medicine and Materia Medica Research,1999,10(11):806-807. |
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| Authors: | Hong Min Zhu Quan Li Xiaodong at alNaming University of TCM |
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| Affiliation: | Hong Min, Zhu Quan, Li Xiaodong,at alNaming University of TCM,210029 |
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| Abstract: | The mechanism of protecting mice from experimental liver injury of alcohol extract of Capillaris decoction wereobserved. Elevated serum ALT,GST activity in D-GaiN LPS liver injury model were reduced by a dose-dependent effect of alcohol extract,coresponding with reduced LPO level. After administration of BCG LPS, serum ALT level increased significantly.Alcohol extract reduced ALT activity and increased GSH level apparently. These results suggest alcohol extract of Capillaris decoction might protect mice from experimental liver injury,through a way of antilipoperoxidation. |
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| Keywords: | Alcohol extract of Capillaris Decoction BCG LPS liver injury D-GaiN LPS liver injury |
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