糖尿病性心肌病患者GLP-1与C-反应蛋白的相关性分析

目的：通过观察糖尿病性心肌病患者的胰高血糖素样肽-1（GLP-1）与炎性因子的相关性,探讨其在糖尿病性心肌病发病机制中的作用.方法：测定50例糖尿病心肌病患者（实验组）和30例健康者（对照组）的血清GLP-1、超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、血压、空腹血糖、餐后2h血糖（2hPG）、空腹血清胰岛素（FINS）,计算稳态模型评价胰岛素抵抗指数（HOMA-IR）.结果：实验组空腹血糖、2hPG、收缩压、FINS、HOMA-IR、hs-CRP、IL-6和TNF-α均显著高于对照组（P〈0.05）,血清GLP-1显著低于对照组（P〈0.05）; GLP-1水平与hs-CRP（r=0.556,P=0.002）和HOMA-IR（r=0.445,P=0.007）呈显著负相关.结论：糖尿病性心肌病的发生发展是GLP-1、炎性因子、胰岛素抵抗等多因素综合作用的结果.

Correlation between GLP-1 and CRP in patients with diabetic cardiomyopathy

AIM：To investigate the correlation between glucagon like peptides-1（GLP-1） and inflammatory cytokines and evaluate mechanism of diabetic cardiomyopathy.METHODS：Serum GLP-1,hyper sensitive C-reactive protein（hs-CRP）,interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,blood pressure,fasting plasma glucose,2 h plasma glucose（2hPG）,fasting serum insulin（FINS） and homeostasis model assessment insulin resistance（HOMA-IR） were measured in 50 patients with diabetic cardiomyopathy（experimental group） and 30 healthy persons（control group）.RESULTS：Compared with control group,fasting plasma glucose,2hPG,systolic pressure,FINS,HOMA-IR,hs-CRP,IL-6 and TNF-α were significantly increased（P0.05）,while serum GLP-1 were reduced in experimental group（P0.05）;serum GLP-1 were negatively correlated with hs-CRP（r=0.556,P=0.002） and HOMA-IR（r=0.445,P=0.007）.CONCLUSION：The occurance and development of diabetic cardiomyopathy is decided by interrelation of GLP-1,inflammatory cytokines and insulin resistance.