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Reprogramming enriches for somatic cell clones with small-scale mutations in cancer-associated genes
Authors:Maike Kosanke  Katarzyna Osetek  Alexandra Haase  Lutz Wiehlmann  Colin Davenport  Adrian Schwarzer  Felix Adams  Marc-Jens Kleppa  Axel Schambach  Sylvia Merkert  Stephanie Wunderlich  Sandra Menke  Marie Dorda  Ulrich Martin
Affiliation:1. Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany;2. Research Core Unit Genomics, Hannover Medical School, 30625 Hannover, Germany;3. Department of Hematology, Oncology and Stem Cell Transplantation, Institute of Experimental Hematology, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany
Abstract:
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  • Keywords:pluripotent stem cells  reprogramming  whole-genome sequencing  genomic integrity  point mutations  INDELs  oncogenes  enrichment  parental cells  endothelial cells
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