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The influence of the abundance and morphology of epileptiform discharges on diagnostic accuracy: How many spikes you need to spot in an EEG
Affiliation:1. Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark;2. Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark; and Department of Clinical Medicine, Aarhus University, Denmark
Abstract:ObjectiveThe operational definition of interictal epileptiform discharges (IEDs) of the International Federation of Clinical Neurophysiology (IFCN) described six morphological criteria. Our objective was to assess the impact of pattern-repetition in the EEG-recording, on the diagnostic accuracy of using the IFCN criteria. For clinical implementation, specificity over 95% was set as target.MethodsInterictal EEG-recordings of 20-minutes, containing sharp-transients, from 60 patients (30 with epilepsy and 30 with non-epileptic paroxysmal events) were evaluated by three experts, who first marked IEDs solely based on expert opinion, and then, independently from the first session evaluated the presence of the IFCN criteria for each sharp-transient. The gold standard was derived from long-term video-EEG recordings of the patientś habitual paroxysmal episodes.ResultsPresence of at least one discharge fulfilling five criteria provided a specificity of 100% (sensitivity: 70%). For discharges fulfilling fewer criteria, a higher number of discharges was needed to keep the specificity over 95% (5 discharges, when only 3 criteria were fulfilled). A sequential combination of these sets of criteria and thresholds provided a specificity of 97% and sensitivity of 80%.ConclusionsPattern-repetition and IED morphology influence diagnostic accuracy.SignificanceSystematic application of these criteria will improve quality of clinical EEG interpretation.
Keywords:Criteria  Definition  Diagnostic accuracy  EEG  Interictal epileptiform discharges  Pattern-repetition
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