| 螺内酯对醛固酮诱导的大鼠肾小球系膜细胞MCP-1表达的影响 |
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| 引用本文： | 徐将,叶山东,董崇周,王明丽,王怡平.螺内酯对醛固酮诱导的大鼠肾小球系膜细胞MCP-1表达的影响[J].安徽医科大学学报,2011,46(4):342-345. |
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| 作者姓名： | 徐将 叶山东 董崇周 王明丽 王怡平 |
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| 作者单位： | 安徽医科大学附属省立医院内分泌科、糖尿病研究室,合肥,230001;安徽医科大学微生物教研室,合肥,230032;澳大利亚悉尼大学移植与肾脏研究中心,悉尼,澳大利亚 |
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| 基金项目： | 安徽省国际科技合作计划 |
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| 摘 要： | 目的 观察螺内酯(Spi)对醛固酮(Ald)诱导的大鼠肾小球系膜细胞(RMCs)表达单核细胞趋化蛋白-1(MCP-1)的影响,探讨其肾脏保护机制.方法 体外培养RMCs,分组如下:NG组(葡萄糖浓度5.6 mmol/L),Ald组(Ald 10-7 mol/L),A组(Spi 10-7 mol/L + Ald 10-7...
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| 关 键 词： | 趋化因子CCL2 螺内酯 醛固酮 肾小球系膜细胞 |
Effects of spironolactone on expression of monocyte chemoattractant protein-1 induced by aldosterone in rat mesangial cells |
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| Xu Jiang,Ye Sh,ong,Dong Chongzhou,et al.Effects of spironolactone on expression of monocyte chemoattractant protein-1 induced by aldosterone in rat mesangial cells[J].Acta Universitis Medicinalis Anhui,2011,46(4):342-345. |
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| Authors: | Xu Jiang Ye Sh ong Dong Chongzhou |
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| Affiliation: | Xu Jiang,Ye Shandong,Dong Chongzhou,et al(Dept of Endocrinology,Institute of Diabetology,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001) |
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| Abstract: | Objective To study the renoprotective mechanisms of spironolactone(Spi) by observing its effect on expression of monocyte chemoattractant protein-1(MCP-1) induced by aldosterone(Ald) in rat mesangial cells(RMCs).Methods RMCs were cultured in vitro and then divided into five group: normal group,group Ald(Ald 10-7 mol/L),group A(Spi 10-7 mol/L and Ald 10-7 mol/L),group B(Spi 10-8 mol/L and Ald 10-7 mol/L),group C(Spi 10-9 mol/L and Ald 10-7 mol/L).RT-PCR was used to measure the expression of mineralocorticoid... |
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| Keywords: | chemokine CCL2 spironolactone aldosterone mesangial cells |
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