流行性乙型脑炎检测神经元烯醇化酶的临床意义

目的:比较普通型与重型儿童流行性乙型脑炎(乙脑)常规实验室检测结果及神经元烯醇化酶浓度,探讨与疾病严重程度相关的危险因素。方法:收集我院2011年1月至2013年12月收治的乙脑住院确诊病例的临床资料,进行回顾性分析。乙脑确诊基于临床特征和血清乙脑IgM阳性结果。结果:38例乙脑确诊病例进入分析,普通型20例,重型18例,男女比例2.8∶1,年龄6月龄至12.5岁,平均(5.1±3.0)岁。常规实验室检查结果:外周血白细胞总数;脑脊液白细胞总数;脑脊液蛋白质含量普通型和重型无明显差异。而无论是外周血清还是脑脊液中神经元烯醇化酶,重型乙脑均明显高于普通型。结论:乙脑的临床分型对判断病情仍有指导意义,血清及脑脊液神经元烯醇化酶浓度可以作为帮助判断患儿病情轻重的客观指标。

The clinical significance of neuron-specific enolase in patients with Japa-nese encephalitis disease

Objective: To understand the clinical features of moderate and severe Japanese encephalitis( JE) in pediatric inpatients and assess the risk factors associated with the severity of Japanese encephalitis. Methods: 38 cases of Japanese encephalitis admitted to North Sichuan Medical College Affiliated Hospital from January 2011 to December 2013. Japanese encephalitis was laboratory-confirmed based on the clinical features and positive JEV-specific immunoglobulin M detection in serum. Results: A total of 38 children confirmed with Japanese encephalitis were included in this study. There are 20 moderate cases and 18 severe cases. The male-to-female ratio was2. 8∶ 1 and the mean age was( 5. 1 ± 3. 0) years old. Results of laboratory test: WBC in peripheral,WBC in CSF,and CSF protein: there are no significant difference between moderate cases and severe cases( P > 0. 05); neuron-specific enolase is higher in the severe cases than in the moderate cases( P < 0. 01). Conclusion: The clinical classification of Japanese encephalitis severity is useful to guide the appropriate management. Neuron-specific enolase is also useful to guide the appropriate management.