| ^99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验 |
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| 引用本文： | 罗世能,谢敏浩.^99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验[J].核技术,1993,16(11):687-689. |
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| 作者姓名： | 罗世能 谢敏浩 |
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| 作者单位： | 江苏省原子医学研究所，江苏省原子医学研究所，江苏省原子医学研究所，江苏省原子医学研究所，江苏省原子医学研究所 无锡 214063，无锡 214063，无锡 214063，无锡 214063，无锡 214063 |
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| 基金项目： | 核医学国家重点实验室和江苏省卫生厅科研项目 |
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| 摘 要： | 实验结果表明，＾９９ｍＴｃ－ＣＤＯ的标记率受体系的ｐＨ值影响较小，而＾９９ｍＴｃ－ＣＤＯ－ＭｅＢ只有在ｐＨ＝３．５－４．０时标记率才能大于９０％。小鼠体内分布实验表明，＾９９ｍＴｃ－ＣＤＯ－ＭｅＢ在动物心肌中较高的吸收，但随时间延长而迅速清除。心／肝比值在给药后１、５和１０ｍｉｎ时分别为３、１．５和０．８。＾９９ｍＴｃ－ＣＤＯ在心、脑中的浓聚明显低于９９ｍＴｃ－ＣＤＯ－ＭｅＢ。
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| 关 键 词： | 环己二酮二肟 甲基硼酸 锝99m |
The preparation and biodistribution of ~(99m)Tc-cyclohexanedione dioxime and its methaneboronic acid adduct |
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| Luo Shineng Xie Minhao Xi Yuefen Feng Yingying Guo Yuzhi.The preparation and biodistribution of ~(99m)Tc-cyclohexanedione dioxime and its methaneboronic acid adduct[J].Nuclear Techniques,1993,16(11):687-689. |
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| Authors: | Luo Shineng Xie Minhao Xi Yuefen Feng Yingying Guo Yuzhi |
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| Abstract: | This paper reports the preparation and biodistribution of 99mTc-cyclo-hexanedione dioxime (99mTc-CDO) and its methaneboronic acid adduct (99mTc-CDO-MeB). The result showed that pH value exerts greater effect on the labelling yield of 99mTc- CDO- MeB than that of 99mTc- CDO. When pH value was 3.5-4.0, the labelling yield of 99mTc-CDO-MeB was higher than 90%. Biodistribution experiment showed that 99mTc-CDO-MeB was taken by heart and brain in the first few minutes after intravenous injection. The uptakes of 99mTc-CDO-MeB by heart and brain were higher than those of 99mTc- CDO. |
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| Keywords: | Technetium- 99m Cyclohexanedione dioxime Methaneboronic acid adduct |
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