肝硬化及乙型肝炎患者血清肿瘤坏死因子水平的研究

采用ELISA方法检测22例肝硬化及110便乙型肝炎患者血清肿瘤坏死因子（TNF）含量。结果显示：肝硬化病人血清TNF水平最高；乙肝慢性迁延型，急性乙肝，乙肝慢性活动性，急性重症乙肝和慢性重症乙肝血清TNF水平则依次升高，与对照组比较均有显著性差异（P＜0．01），并发现肝硬化和慢性重症乙肝合并腹腔感染者血清TNF水平也显著高于未合并感染者（P＜0．01）。结果揭示血清TNF水平与肝硬化和乙肝类型密切相关，血清TNF水平对肝硬化和乙肝类型的诊断，疗效判断均具有一定的参考价值。

A Study of TNF Level in Serum of Patients with Hepatic Cirrhosis and Hepatitis B

The levels of tumor necrosis factor (TNF) in serum of 22 patients with hepatic cirrhosis,110 patients with hapatitis B and 20 blood donors were detected by ELISA.The results showed that the level of TNF in serum of patients with hepatic cirrhosis was the highest.The elevations in serum level of TNF in order were chronic persistent hepatitis B,acute severe hepatitis B,chronic active hepatitis B,acute severe hepatitis B and chronic severe hepatitis B respectively,significantly different form that of normal ( P < 0.01 ),and that the level of TNF in serum was higher in patients with hepatic cirrhosis or chronic hepatitis B complicated with infection in abdominal cavity than in those without infection ( P < 0.01 ).It is indicated that the level of TNF in serum is closely correlated with hepatic cirrhosis and types of hepatitis B and is valuable for reference in the diagnosis of hepatic cirrhosis and types of hepatitis B and judgement of therapeutic effects.