Single nucleotide polymorphisms in sporadic colorectal cancer |
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Authors: | Martha L Slattery PhD MPH |
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Affiliation: | (1) Health Research Center, University of Utah, 375 Chipeta Way, Suite A, 84108 Salt Lake City, UT, USA |
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Abstract: | Colorectal cancer (CRC) etiology involves multiple disease pathways. An important research element for unraveling these carcinogenic
pathways to CRC is to gain an understanding of genetic susceptibility to CRC at the population level; single nucleotide polymorphisms
(SNPs) are central to this research. Examination of a broad spectrum of SNPs along multiple disease pathways should help our
understanding of cancer biology and the carcinogenic process. However, one of the greatest research challenges today will
be to implement and interpret studies that utilize SNPs to gain insight into the genetic susceptibility of CRC. |
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