胃癌根治术后早期复发的临床病理特点及预后分析

目的:探讨胃癌根治术后早期复发的相关因素及预后分析。方法:回顾性分析235例胃癌根治术后复发患者的临床病理资料，对相关参数进行单因素和多因素分析。Kaplan-Meier法进行预后的生存分析。结果:235例患者平均复发时间为术后24.3个月，其中早期复发145例（≤2年），晚期复发90例（＞2年）。单因素分析显示手术方式、肿瘤大小、脉管侵犯、浸润深度、淋巴结转移、TNM分期、术后化疗与早期复发相关（P<0.05）。多因素分析显示肿瘤大小（P=0.001）、淋巴结转移（P=0.007）、术后化疗（P=0.011）是早期复发的独立影响因素。生存分析显示肿瘤大小（P=0.013）、TNM分期（P<0.01）是预后的独立影响因素。结论:肿瘤大小、淋巴结转移、术后化疗是胃癌早期复发的独立影响因素，且预后与肿瘤大小、TNM分期密切相关。

Clinicopathologic and prognostic factors related to early recurrence of gastric cancer after curative radical resection

Objective:To explore the clinicopathologic factors and prognosis related to early recurrence of gastric cancer after curative radical resection.Methods:A retrospective clinical analysis was made in 235 patients with gastric cancer，who recurred after curative radical resection.Clinicopathologic factors related to tumor recurrence were studied and survival analysis was performed using Kaplan-Meier plots.Results:The mean time from curative surgery to recurrence in 235 patients was 24.3 months，among whom 145 experienced recurrence within 2 years （early recurrence group） and 90 recurred more than 2 years （late recurrence group）.Univariate analysis showed that operation type，tumor size，lymphovascular invasion，depth of invasion，lymph node metastasis，TNM stage，adjuvant chemotherapy were associated with the time of recurrence （P<0.05）.In multivariate analysis，tumor size （P=0.001），lymph node metastasis （P=0.007） and adjuvant chemotherapy （P=0.011） were independent factors.Survival analysis showed that tumor size （P=0.013） and TNM stage （P<0.01） were independent prognostic factors.Conclusion:Tumor size，lymph node metastasis and adjuvant chemotherapy were independent factors of early recurrence with gastric cancer after curative radical resection.Tumor size and TNM stage were both important prognostic factors.