| 他汀类药物代谢相关基因多态性与其不良反应发生的相关性 |
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| 引用本文： | 高洋洋,樊萍,黄跃洲,杨梅梅,徐珽.他汀类药物代谢相关基因多态性与其不良反应发生的相关性[J].中国医院药学杂志,2018,38(3):280-284. |
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| 作者姓名： | 高洋洋 樊萍 黄跃洲 杨梅梅 徐珽 |
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| 作者单位： | 四川大学华西医院临床药学部, 四川 成都 610041 |
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| 摘 要： | 目的:为他汀类药物的临床精准用药,预防和减少不良反应(ADR)的发生提供参考。方法:收集近年来国内外有关他汀类药物基因多态性与其ADR的参考文献,对他汀类基因多态性与其ADR的相关性进行归纳和总结。结果:药物代谢酶和转运体的相关基因多态性是影响他汀类药物ADR发生的重要因素。结论:基因多态性研究可为预防他汀类药物的ADR提供参考依据,临床可在服用他汀类药物前对患者进行基因型检测,以降低ADR的发生率。
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| 关 键 词： | 他汀类药物 ADR 基因多态性 药物代谢酶 转运体 |
| 收稿时间： | 2017-06-19 |
Relationship between gene polymorphisms and adverse effect of statins |
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| GAO Yang-yang,FAN Ping,HUANG Yue-zhou,YANG Mei-mei,XU Ting.Relationship between gene polymorphisms and adverse effect of statins[J].Chinese Journal of Hospital Pharmacy,2018,38(3):280-284. |
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| Authors: | GAO Yang-yang FAN Ping HUANG Yue-zhou YANG Mei-mei XU Ting |
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| Affiliation: | Department of Pharmacy, West China Hospital of Sichuan University, Sichuan Chengdu 610041, China |
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| Abstract: | OBJECTIVE To provide a reference for precision medication in the clinic,preventing and reducing the occurrence of statins ADRs.METHODS Foreign and domestic literatures about statins and ADRs were collected to summarize the relationship of genetic polymorphisms with ADRs.RESULTS The important factors to influence the occurrence of statin ADR were drug metabolites and transporters.CONCLUSION Gene polymorphism study can provide a reference for the prevention of statins ADRs.Gene detection can be conducted before statins induce ADRs. |
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| Keywords: | statins ADR polymorphism drug metabolites transporter |
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