| NKT细胞的生物特性及其在多发性骨髓瘤中应用的研究进展 |
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| 引用本文： | 姜凤娟,付蓉.NKT细胞的生物特性及其在多发性骨髓瘤中应用的研究进展[J].中国肿瘤临床,2018,45(17):904-907. |
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| 作者姓名： | 姜凤娟 付蓉 |
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| 作者单位： | 天津医科大学总医院血液科（天津市300052） |
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| 基金项目： | 天津市抗癌重大专项攻关计划项目12ZCDZSY18000天津市卫生局重大攻关项目15KG150 |
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| 摘 要： | NKT细胞是一种特殊的T淋巴细胞亚群，其表面既有T细胞受体，又有NK细胞受体。NKT细胞在肿瘤、自身免疫性疾病和微生物感染中起到调节免疫应答的作用，是联系固有免疫和获得性免疫的“桥梁”之一。多发性骨髓瘤（multiple myeloma，MM）是一种浆细胞异常增殖的恶性血液系统疾病。MM细胞表达CD1d分子并且可被具有CD1d限制性的NKT细胞杀伤。近些年，NKT细胞的抗MM作用成为研究热点，本文就NKT细胞生物特性及其在MM治疗中的应用进行综述。
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| 关 键 词： | NKT细胞 多发性骨髓瘤 应用 治疗 |
| 收稿时间： | 2018-07-17 |
Biological properties of natural killer T cell and its applications in multiple myeloma |
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| Affiliation: | Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China |
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| Abstract: | Natural killer T (NKT) cells constitute a distinct subpopulation of T cells that express T-cell receptors and NKT cell markers. NKT cells are one of the bridges that link the innate and adaptive immune systems and play a vital role in regulating immune responses in tumors, autoimmune diseases, and microbial infection. Multiple myeloma is a hematologic malignancy due to the uncontrolled proliferation of plasma cells. Multiple myeloma cells express CD1d and are sensitive to lysis by CD1d-restricted natural killer T cells. In recent years, the antitumor effects of NKT cells in multiple myeloma have become a hot research topic. Here, we reviewed the biological characteristics of NKT cells and their applications in multiple myeloma. |
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