鼻用激素缓解季节性过敏性鼻炎眼部症状的疗效观察

 目的 观察鼻用激素(糠酸莫米松喷鼻剂)缓解季节性过敏性鼻炎(seasonal allergic rhinitis, SAR)眼部症状的疗效。方法 针对SAR主要鼻眼症状,制定4分度自评量表(无症状=0、轻度=1、中度=2、重度=3),收集2016-08至2017-04我院门诊就诊患者中符合标准的伴眼部症状SAR患者共计156例,以用药前医师评分作为基线,以后给予糠酸莫米松喷鼻剂200 μg(50 μg/喷,每侧鼻孔2喷/次,1次/d)喷鼻治疗,并由患者每日用药前自评。治疗结束后收集评分表,将每日鼻眼评分分别相加得出鼻、眼总分,对照基线变化,分析比较症状缓解程度,评价疗效。结果 共计156例纳入研究,103例完成研究。第一次用药24 h后,鼻眼症状评分即迅速下降。鼻部症状评分用药2次后进入稳定期;眼部症状用药4次后进入稳定期。治疗前后各组鼻、眼症状评分变化具有统计学差异(鼻部评分:F=533.500,P＜0.01;眼部评分:F=362.188,P＜0.01)。用药期间未发生不良反应。结论 糠酸莫米松喷鼻剂在缓解鼻部症状同时,可以缓解眼部症状,在治疗伴眼部症状的SAR时,单药治疗即可获得显著疗效。

Alleviation of ocular symptoms with intranasal corticosteroid among seasonal allergic rhinitis patients

Objective To observe the therapeutic effect of intranasal corticosteroid mometasone furoate against ocular symptoms of patients with seasonal allergic rhinitis.Methods A total of 156 patients were recruited according to the primary nasal and ocular symptoms of seasonal allergic rhinitis between August 2016 and April 2017. We made a four-grade (none=0, mild=1, moderate= 2, severe=3) self-assessment scale. The first score was assessed by physicians as baseline before administration. Then, the patients received momestasone furoate spray 200 μg once daily (50 μg twice for one nostril), and the nasal and ocular symptom scores were assessed by patients before daily administration. The total nasal and ocular scores were calculated and compared with baseline to assess the therapeutic effect.Results 103 patients completed the study. The total nasal and ocular symptom scores were reduced remarkably 24h after the first medication. The total nasal symptom score became stable after medication twice, and the total ocular symptom score became stable after four-time medication. The significant difference of the total nasal and ocular symptom scores between these groups was confirmed with ANOVA (nasal symptom: F=533.500,P＜0.01; ocular symptom: F=362.188,P＜0.01). No adverse events were found during the treatment.Conclusions Intranasal corticosteroin mometasone furoate can relieve both nasal and ocular symptoms significantly. This single agent can be used to relieve the symptoms of seasonal allergic rhinitis with ocular problems effectively.