基于Oncomine数据库分析Pygopus2基因在乳腺癌组织中的表达及其临床意义

目的 探讨Pygopus2（PYGO2）基因在乳腺癌组织中的表达及临床意义。方法 收集Oncomine数据库中关于PYGO2的信息，利用Kaplan-Meier Plotter数据库分析PYGO2与乳腺癌患者预后的关系。结果 Oncomine数据库中共收集了45项研究（包括3 730个样本）涉及PYGO2在乳腺癌组织和正常组织中表达的比较。与正常组织相比，PYGO2在乳腺癌组织中高表达（P<0.05）。PYGO2高表达组乳腺癌患者的总体生存率（HR=0.69，95%CI：0.51~0.95，P=0.021）、无复发生存率（HR=0.60，95%CI：0.51~0.70，P<0.001）以及无远处转移生存率（HR=0.61，95%CI：0.43~0.87，P=0.005）均优于低表达组。结论 PYGO2在乳腺癌组织中高表达，且与乳腺癌患者不良预后有关，可能是评估乳腺癌患者预后的潜在生物标志物。

Expression of Pygopus2 and its prognostic role in breast cancer: an analysis based on the data-mining of Oncomine

Objective To explore the expression of Pygopus2 （PYGO2） and its clinical significance in breast cancer. Methods PYGO2 data were retrieved from the Oncomine database and the relationship between PYGO2 and prognosis of breast cancer patients was retrieved from an online survival analysis tool “Kaplan-Meier Plotter” database. Results A total of 45 studies （including 3，730 samples） were involved PYGO2 in breast cancer tissues and normal tissues. PYGO2 expression levels in breast cancer was higher than that in normal tissues（P<0.05）. Kaplan-Meier Plotter of survival analysis indicated that high expression of PYGO2 was closely associated with better survival in breast cancer，including overall survival （HR=0.69，95%CI: 0.51-0.95，P=0.021），relapse-free survival （HR=0.60，95%CI: 0.51-0.70，P<0.001） and distant metastasis-free survival （HR=0.61，95%CI: 0.43-0.87，P=0.005）. Conclusion PYGO2 is highly expressed in breast cancer tissues and associated with poor prognosis in breast cancer patients，which may be a potential biomarker for estimating the prognosis of breast cancer.