| 通心络对实验性家兔主动脉粥样斑块CAM-1表达影响的实验研究 |
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| 引用本文： | 张路,吴宗贵.通心络对实验性家兔主动脉粥样斑块CAM-1表达影响的实验研究[J].中西医结合心脑血管病杂志,2003,1(12):705-706. |
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| 作者姓名： | 张路 吴宗贵 |
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| 作者单位： | 上海第二军医大学附属长征医院 |
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| 摘 要： | 目的 :观察通心络对动脉粥样斑块VCAM -1和ICAM -1表达的影响。方法 :构建实验性家兔主动脉粥样硬化模型 ,随机抽签分组 ,通心络组 8只 ,高脂饮食组 8只。另设普通饲料喂养兔 5只组成空白对照组。采用免疫组织化学方法 ,测定各组VCAM -1、ICAM -1信号强度。结果 :通心络可一定程度减少动脉粥样斑块VCAM -1和ICAM -1的表达 ,通心络组VCAM -1和ICAM -1均低于高脂饮食组 (P <0 .0 5 )。结论 :通心络可延缓粥样斑块形成的进程。
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| 关 键 词： | 通心络 实验 家兔 主动脉粥样斑块 CAM-1 细胞间黏附分子-l |
| 文章编号： | 1672-1349(2003)12-705-02 |
| 修稿时间： | 2003年10月13 |
Experimental Study on the Effects of Tongxinluo on the Expression of Cell Adhesion Molecule 1 in Rabbit Aortic Atherosclerotic Plaques |
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| Zhang Lu,Wu Zonggui.Experimental Study on the Effects of Tongxinluo on the Expression of Cell Adhesion Molecule 1 in Rabbit Aortic Atherosclerotic Plaques[J].Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease,2003,1(12):705-706. |
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| Authors: | Zhang Lu Wu Zonggui |
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| Affiliation: | Shanghai 200003 |
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| Abstract: | Objective: To investigate the effects of Tongxinluo on the expression of vascular cell adhesion molecule-1(VCAM-1) and intercellular adhesion molecule-1(ICAM-1) in rabbit aortic atherosclerotic plaques. Methods: The rabbit aortic atherosclerotic model was developed by high cholesterol feeding. The protein levels of VCAM-1 and ICAM-1 in atherosclerotic plaques were studied by means of immunohistochemistry. Results: Tongxinluo decreased the protein levels of VCAM-1 and ICAM-1 in atherosclerotic plaques. Conclusion: Tongxinluo can decelerate the progression of atherosclerosis. |
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| Keywords: | Cell adhesion molecule Atherosclerosis Aortic Tongxinluo |
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