| 微波辐射合成7-羟基-4-甲基香豆素 |
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| 引用本文： | 李西安,马霞.微波辐射合成7-羟基-4-甲基香豆素[J].化学世界,2008,49(11). |
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| 作者姓名： | 李西安 马霞 |
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| 作者单位： | 延安大学化学与化工学院,陕西,延安,716000 |
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| 摘 要： | 以硫酸氢钠为催化剂,采用微波辐射,由间苯二酚与乙酰乙酸乙酯缩合制备7-羟基-4-甲基香豆素。结果表明,微波辐射合成7-羟基-4-甲基香豆素的最佳反应条件为:n(间苯二酚)∶n(乙酰乙酸乙酯)=1.0∶1.0,硫酸氢钠0.4 g,10 mL环己烷,反应温度100℃,微波辐射时间12 min,微波功率500 W,产率91.0%。
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| 关 键 词： | 硫酸氢钠 7-羟基-4-甲基香豆素 微波辐射 合成 |
Synthesis of 7-Hydroxy-4-methylcoumarin under Microwave Irradiation |
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| LI Xi-an,MA Xia.Synthesis of 7-Hydroxy-4-methylcoumarin under Microwave Irradiation[J].Chemical World,2008,49(11). |
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| Authors: | LI Xi-an MA Xia |
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| Abstract: | The synthesis of 7-hydroxy-4-methylcoumarin was performed by the condensation of 1,3-benzenediol and ethyl acetoacetate under microwave irradiation.The optimum reaction conditions were as follows:5.8 g 1,3-benzenediol,6.8 mL ethyl acetoacetate,0.4 g sodium hydrogen sulfate,10 mL cyclohexane,100(℃),12 min,and microwave irradiation with 500 W microwave power.The yield reached 91.0% |
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| Keywords: | sodium hydrogen sulfate 7-hydroxy-4-methylcoumarin microwave irradiation synthesis |
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