| 胆碱对小鼠中枢镇痛效应的特征 |
| |
| 引用本文： | 苏冬梅,刘跃,王越,王汝欢,汪海. 胆碱对小鼠中枢镇痛效应的特征[J]. 金属学报, 2004, 9(11): 1217-1220 |
| |
| 作者姓名： | 苏冬梅 刘跃 王越 王汝欢 汪海 |
| |
| 作者单位： | 1.军事医学科学院毒物药物研究所,北京 100850;2.山东大学医学院,济南 250012,山东;3.赛德维康医药研究院,北京 100850 |
| |
| 基金项目： | 国家自然科学基金资助项目(No30371641);北京赛德维康医药研究院新药研究基金项目资助(No1999001) |
| |
| 摘 要： | 目的: 研究胆碱中枢镇痛效应的药效学特征。方法: 通过小鼠热板实验观察不同剂量胆碱的镇痛作用及多种拮抗剂对其镇痛作用的影响,探讨胆碱镇痛作用的可能途径。结果: 胆碱（90~120 μg/只）可以产生镇痛作用,且能被MLA(50 μg/只）、α-银环蛇毒素（2 μg/只）和阿托品（0.1 μg/只）所拮抗,但不能被美加明（5 μg/只）和纳洛酮（2 μg/只）所拮抗。结论: 胆碱镇痛作用可能通过α7烟碱受体亚型介导,且可能与M受体有关。
|
| 关 键 词： | N受体激动剂 胆碱 α7烟碱受体亚型 镇痛 热板实验 |
| 收稿时间： | 2004-07-13 |
| 修稿时间： | 2004-08-24 |
Characteristics of antinociceptive effects of choline in central nervous system in mice |
| |
| SU Dong-Mei,LIU Yue,WANG Yue,WANG Ru-Huan,WANG Hai. Characteristics of antinociceptive effects of choline in central nervous system in mice[J]. Acta Metallurgica Sinica, 2004, 9(11): 1217-1220 |
| |
| Authors: | SU Dong-Mei LIU Yue WANG Yue WANG Ru-Huan WANG Hai |
| |
| Affiliation: | 1.Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;2.Medicine College of Shandong University,Jinan 250012, Shandong, China;3.Thadweik Academy of Medicine, Beijing 100850, Chirm |
| |
| Abstract: | AIM: To investigate the characteristics of the antinociceptive effects of choline in central nervous system (CNS) in mice. METHODS: Hot-plate test (icv) was used to study the antinociceptive effects of cho-line, the influences of many antagonists on the antinoci-ceptive effects of choline were observed, the potential mechanisms underlying the antinociceptive effects of cho-line were discussed. RESULTS: With the administration of choline 90-120 μg per mouse, antinociceptive effects showed in a dose-dependent manner. MLA(50 μg per mouse), a-BTX(2 μg per mouse) and atropine(0.1 μg per mouse) significantly blocked the effect of choline; mecamylamine(5 μg per mouse) and naloxone(2 μg per mouse) failed to block choline-induced antinociception. CONCLUTION: Choline-induced antinociception is me-diated by α7-nAchR subtype, while mAchR seems to be related to choline-induced antinociception. |
| |
| Keywords: | nAchR agonist choline α7-nAchR subtype antinociceptive effect hot-plate |
|
| 点击此处可从《金属学报》浏览原始摘要信息 |
|
点击此处可从《金属学报》下载全文 |
|
