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Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation
Authors:Sharon Morein-Zamir  Kevin J Craig  Karen D Ersche  Sanja Abbott  Ulrich Muller  Naomi A Fineberg  Edward T Bullmore  Barbara J Sahakian  Trevor W Robbins
Affiliation:(1) Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Hills Road, Box 189, CB2 2QQ Cambridge, UK;(2) Behavioral and Clinical Neurosciences Institute (BCNI), University of Cambridge, Cambridge, UK;(3) Department of Experimental Psychology, University of Cambridge, Cambridge, UK;(4) Department of Psychiatry, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK;(5) Postgraduate Medical School, University of Hertfordshire, Hatfield, UK;(6) GlaxoSmithKline, Clinical Unit Cambridge, Cambridge, UK;(7) P1vital Ltd., Oxford, UK
Abstract:

Rationale  

Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well.
Keywords:
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