血清菱形结构域蛋白、胃蛋白酶原和癌胚抗原对胃癌的早期诊断价值

目的评价菱形结构域蛋白1(RHBDD1)、胃蛋白酶原(PGⅠ、PGⅡ)以及癌胚抗原(CEA)在慢性萎缩性胃炎的筛查中的作用,评价其对胃癌早期诊断的价值。方法收集2016年1月至2017年1月在北京医院接受胃镜及胃黏膜病理检查的患者共78例。根据病理结果将研究对象分为慢性浅表性胃炎(CSG)11例、慢性萎缩性胃炎(CAG)18例、低级别上皮内瘤(LGIN)10例、早期胃癌(EGC)23例、进展期胃癌(AGC)16例。分别检测各组患者的血清CEA、胃蛋白酶原、RHBDD1,应用统计学方法对上述检验结果进行统计分析。结果PGⅠ/Ⅱ在5组间比较差异明显(P<0.05);两两比较中,CSG-EGC、CSG-AGC、CAG-AGC和LGIN-AGC组间差异明显(P<0.05)。以胃炎-早期胃癌-进展期胃癌分组,CEA及PGⅠ/Ⅱ具有统计学差异(P<0.05);RHBDD1呈上升趋势。结论PGⅠ/Ⅱ水平减低对早期胃癌具有诊断价值,可用于胃癌高危患者的早期筛查。

Value of serum RHBDD1,pepsinogen and CEA in the early diagnosis of gastric cancer

Objective To evaluate the usefulness of RHBDD1,pepsinogen(PGI and PGII)and CEA in screening atrophic gastritis,and to evaluate the value of them in early diagnosis of gastric cancer.Methods We collected 78 patients from January 2016 to January 2017 who underwent gastroscopy and pathological examination of gastric mucosa in Beijing Hospital.They were divided into five groups according pathological results:CSG11cases,CAG18 cases,LGIN10 cases,EGC23 cases,AGC16 cases.Serum CEA,pepsinogen and RHBDD1 of the patients were measured.Then all the results were analysed by using SPSS19.0.Results The levels of PGⅠ/Ⅱwere statistically significant different among 5 groups(P<0.05).There was statistical difference in comparing of CSG-EGC,CSG-AGC,CAG-AGC and LGIN-AGC groups(P<0.05).Level of CEA and PGⅠ/Ⅱamong gastritis,early gastric cancer and advanced gastric cancer was statistically different as well(P<0.05),a RHBDD1 was in ascending trend among these three groups.Conclusions Low level of PGⅠ/Ⅱcan be used in early screening and early diagnosis of gastric cancer.