| Intrastriatal Gene Transfer of Vascular Endothelial Growth Factor Rescues Dopaminergic Neurons in a Rat Parkinson's Disease Model |
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| 作者姓名： | 田有勇 孙圣刚 汤翠菊 王家宁 陈小武 乔娴 |
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| 作者单位： | Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Institute of Clinical Medicine the Affiliated People's Hospital of Yunyang Medical College，Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430030 China，Shiyan 442000 China，Wuhan 430022 China，Wuhan 430022 China |
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| 摘 要： | Parkinson's disease (PD) is a chronic progressivegerontic disease, which is characterized by the degeneration of dopaminergic neurons in substantia nigra. Efforhas been made to find effective treatment to arrest oslow down the degeneration of dopaminergic neuronsOnce regarded as an endothelial cell-specific factorvascular endothelial growth factor (VEGF), in recenyears, was unexpectedly found to be a critical player inneurodegeneration, and have direct neurotrophic andneuroprotective effects…
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| 关 键 词： | vascular endothelial growth factor A Parkinson’s disease gene therapy gene transfer technique |
Intrastriatal Gene Transfer of Vascular Endothelial Growth Factor Rescues Dopaminergic Neurons in a Rat Parkinson's Disease Model |
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| TIAN Youyong,SUN Shenggang,TANG Cuiju,WANG Jianing,CHEN Xiaowu,QIAO Xian.Intrastriatal Gene Transfer of Vascular Endothelial Growth Factor Rescues Dopaminergic Neurons in a Rat Parkinson's Disease Model[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(6). |
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| Authors: | TIAN Youyong SUN Shenggang TANG Cuiju WANG Jianing CHEN Xiaowu QIAO Xian |
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| Abstract: | To examine the ability of intrastriatal gene transfer of vascular endothelial growth factor 165 mediated by adenoviral vector to rescue dopaminergic neurons in a rat model of Parkinson's disease (PD), we constructed recombinant replication-deficent adenoviral vectors carrying the gene of VEGF165 (Ad-VEGF), and injected Ad-VEGF (or Ad-LacZ and PBS as controls) into the striatum of rats 7 days after the lesion by 6-hydroxydopamine. The rat rotational behavior analysis and tyrosine hydroxylase (TH) immunohistochemistry were performed to assess the change of dopaminergic neurons. Our results showed that the rats receiving Ad-VEGF injection displayed a significant improvement in apomorphine-induced rotational behavior and a significant preservation of TH-positive neurons and fibers compared with control animals. It is concluded that intrastriatal gene transfer by Ad-VEGF may rescue the dopaminergic neurons from degeneration in a rat model of PD. |
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| Keywords: | vascular endothelial growth factor A Parkinson's disease gene therapy gene transfer technique |
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