| 老年脑胶质瘤患者应用化疗药物的毒副反应研究 |
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| 引用本文： | 孙祥冬,舒卫权,冯江,徐军,李键.老年脑胶质瘤患者应用化疗药物的毒副反应研究[J].老年医学与保健,2011,17(1):49-51. |
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| 作者姓名： | 孙祥冬 舒卫权 冯江 徐军 李键 |
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| 作者单位： | 复旦大学附属华东医院神经外科,上海市,20040 |
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| 摘 要： | 目的探讨老年脑胶质瘤患者应用化疗药物后的毒副反应。方法将146例应用化疗药物的脑胶质瘤患者根据年龄分为老年组70例（≥60岁）和中青年组76例（〈60岁），然后进行组间比较，所有患者均采用替尼泊甙（VM-26）＋司莫司汀（Me-CCNU）联合化疗方案。结果老年组的骨髓抑制现象和呕吐反应（25．0％和23．9％）并不高于中青年组（23．8％和24．2％）（P〉0．05）。结论老年脑胶质瘤患者实施化疗是安全的，毒副反应并没有增加。
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| 关 键 词： | 老年人 脑胶质瘤 化疗 毒副反应 |
Study on the side effect in chemotherapy for elderly patients with brain glioma |
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| SUN Xiang-dong,SHU Wei-quan,FENG Jiang,XU Jun,LI Jian.Study on the side effect in chemotherapy for elderly patients with brain glioma[J].Geriatrics & Health Care,2011,17(1):49-51. |
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| Authors: | SUN Xiang-dong SHU Wei-quan FENG Jiang XU Jun LI Jian |
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| Affiliation: | . (Department of Neurosurgery, Huadong Hospital, Fudan University, Shanghai 200040, China) |
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| Abstract: | Objective To explore the toxic reaction of chemotherapy for older patients with brain glioma. Methods 146 patients with brain glioma were divided into two groups： age ≥60 years group and age 〈60 years group. 70 patients each group. All the patients were treated with VM-26 and Me-CCNU. The side effects in the two groups were compared. Results There were no differences in the myelotoxicity and the vomit between the two groups （ 25.0 % vs 23.8 %; 23.9 % vs 24.2% ）. Conclusions The chemotherapy in the elderly patients with brain glioma is safe and has little side effect. |
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| Keywords: | Elderly Brain glioma Chemotherapy Side effect |
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