以血清肌酐为变量估算肾小球滤过率新公式的创建

目的创建准确、简便、安全、廉价、合理的估算肾小球滤过率（eGFR）新公式。方法用99mTc-DTPA清除率准确测定136例受试者GFR（Tc—GFR），同时测定血清肌酐（SCr）等多种临床指标，经相关及回归等统计学分析，求出基于SCr的成年中国人eGFR（SCrAC．eGFR）新公式。另选117例受试者，以同法准确测定其Tc—GFR，同时测SCr与尿素氮，以SCrAC-eGFR、美国DMS法等12条公式eGFR，所得数据进行相关分析与对比研究。结果所求得的新公式成立，其回归系数差异有统计学意义（P〈0．01）；SCrAC—eGFR新公式、美国DMS法、日本苦味酸法等6条公式的eGFR均能在一定程度上准确反映肾小球滤过率，而以SCrAC-eGFR新公式和美国DMS法公式更准确，可代替Tc-GFR应用于临床。结论SCrAC—eGFR新公式、美国DMS法等6条公式均为准确、简便、快速、安全、廉价而合理的估算肾小球滤过率方法，值得临床推广应用。

The establishment of the new formula for estimating glomerular filtration rate based on the serum creatinine

Objective To establish an accurate, simple, safe, cheap, and logical new adult Chinese formula for measurement and calculation of glomerular filtration rate （eGFR）. Methods GFRs from 136 cases of patients in hospital suffering from the different diseases were determined accurately using clearance rate of 99mTc-DTPA （Te-GFR）, and many clinical factors including serum creatinine （SCr） were determined simultaneously with routine method. The new equation for adult Chinese based on the SCr was obtained by the relationship and regression analysis for measurement and calculation GFR （SCrAC-eGFR）. Tc-GFR from another 117 cases of patients were determined by the same method. SCr, and blood urea nitro- gen were determined using routine method, eGFR were measured and calculated by 12 formulae such as SC- rAC-eGFR, and USA DMS method. The relationship analysis and the contrast study from all data were per- formed. Results The equation was tenable, and the regression coefficient was significant （ P 〈 0. 01 ）. eGFR from the six formulae for example SCrAC-eGFR, USA DMS method, Japan Picric method and so on could all give expression to GFR accurately at the some extent and the SCrAC-eGFR new formulae and USA DMS method formulae was more accurately than other and could take the place of Tc-GFR clinically. Conclusions The six formulae including SCrAC-eGFR, and USA DMS method were all accurate, simple, celer, safe, cheap, and rational methods for estimating GFR. It should apply and popularize clinically.