浙江省一农村社区迟发性性腺功能减退症的调查研究

目的:调查乡村中老年男性迟发性性腺功能减退症(LOH)的流行病学情况。方法:2012年4～10月在浙江省嘉兴市嘉善县魏塘乡村采用年龄分层抽样选取996例40～80岁的中老年男性进行中老年男子雄激素缺乏(ADAM)、老年男子症状(AMS)和国际勃起功能问卷-5(IIEF-5)调查,同时测定血清中总睾酮(TT)、性激素结合球蛋白(SHBG)及白蛋白(ALB)水平,Vermeulen公式计算游离睾酮(cFT)及生物可利用睾酮(Bio-T)水平,超声检测前列腺、睾丸体积。结果:研究对象年龄(56.22±8.82)岁,ADAM及AMS筛查LOH的患病率分别为62.86%和23.05%;ED阳性率为68.83%,SHBG、LH、cFT及Bio-T筛查LOH各组之间存在统计学差异。结论:浙江省嘉善县魏塘乡村中老年男性LOH筛查率较国内其他报告(特别是大中城市)LOH筛查率低,ED患病率接近。城乡中老年LOH患病率有差别,值得进一步研究。

Late-onset hypogonadism among old and middle-aged males in a rural community of Zhejiang Province

Objective: To investigate the epidemiology of late-onset hypogonadism(LOH) in old and middle-aged males in the rural area of Southern China.Methods: Using the age-stratified sampling method,we conducted a questionnaire investigation on androgen deficiency in aging males(ADAM),aging male symptoms(AMS) and IIEF-5 among 996 males aged 40-80 years in a rural community of Jiashan county,Zhejiang Province from April to October 2012.We also determined the concentrations of serum total testosterone(TT),serum sex hormone binding globulin(SHBG) and serum albumin(ALB),detected the levels of free testosterone(cFT) and bio-available testosterone(Bio-T) by Vermeulen formula,and measured the volumes of the prostate and testis by ultrasonography.Results: The mean age of the males was 56.22±8.82 years.The positive rates of LOH were 62.86% and 23.05% based on ADAM and AMS,respectively,and the incidence of erectile dysfunction(ED) was 68.83%.There were significant differences among different age groups in the levels of luteinizing hormone(LH),SHBG,cFT and Bio-T,but not in TT concentration.Conclusion: Ours was the first survey on the epidemiology of LOH among old and middle-aged males in the rural area of China.The incidence of LOH in the rural community of Zhejiang Province was lower than that in the urban areas reported in other studies,but the positive rate of ED showed no significant difference.