| 载体介导的布鲁氏菌疫苗的研制现状 |
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| 引用本文： | 李文桂,陈雅棠.载体介导的布鲁氏菌疫苗的研制现状[J].国外医学：医学地理分册,2019(2):97-104. |
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| 作者姓名： | 李文桂 陈雅棠 |
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| 作者单位： | 重庆医科大学附属第一医院传染病寄生虫病研究所 |
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| 基金项目： | 国家自然科学基金资助项目(30801052、30671835、30500423、30200239) |
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| 摘 要： | 布鲁氏菌引起的布鲁氏菌病是一种严重危害人畜健康的传染性疾病,采用疫苗防治该菌是当前研究的热点领域之一。OMP、SOD和L7/L12抗原是3种有效的疫苗候选分子,本文综述了鼠伤寒沙门氏菌、乳酸乳球菌、卡介苗、人赭菌、根癌农杆菌、大肠埃希菌、小肠结肠耶尔森菌、毕赤酵母、禽流感病毒、Semliki森林病毒、山羊痘病毒、牛痘病毒、腺病毒血清型5、伪狂犬病毒和昆虫杆状病毒等载体介导的布鲁氏菌疫苗的研制现状。
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| 关 键 词： | 布鲁氏菌 OMP蛋白 SOD抗原 L7/L12抗原 疫苗 |
The statusin the research of vaccine of Brucella mediated by vectors |
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| LI Wengui,CHEN Yatang.The statusin the research of vaccine of Brucella mediated by vectors[J].Foreign Medical Sciences(Section of Medgeography),2019(2):97-104. |
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| Authors: | LI Wengui CHEN Yatang |
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| Affiliation: | (Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Brucellosis caused by Brucella is one type of infectious diseases seriously endandering human and animal health,it recently becomes highlight to control this bacteria by use of the vaccine.OMP,SOD and L7/L12 antigen are 3 types of effective candidate molecules of vaccine,the review outlines the status in the research of vaccine of Brucella mediated by bacteria such as Salmonella typhimurium,Lactococcus lactis,Bacille calmette-Guerin,Ochrobactrum anthropi,Agrobacterium tumefacies,Escherichia coli,Yersinia enterocolitica,and Pichia pastoris,viruses such as Avian Influenza Virus,Semliki forest virus,Goat poxvirus,Vaccinia virus,Adenovirus serotype 5,Pseudorabies Virus,and Baculovirus. |
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| Keywords: | Brucella OMP antigen SOD antigen L7/L12 antigen vaccine |
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