| 甲硝羟乙唑衍生物对L_(7712)细胞膜通透性的影响 |
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| 引用本文： | 孟祥顺,赵芳,郑秀龙.甲硝羟乙唑衍生物对L_(7712)细胞膜通透性的影响[J].第二军医大学学报,1988(5). |
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| 作者姓名： | 孟祥顺 赵芳 郑秀龙 |
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| 作者单位： | 第二军医大学放射医学研究室
(孟祥顺，赵芳)，第二军医大学放射医学研究室(郑秀龙) |
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| 摘 要： | 本文报告了辐射增敏剂甲硝羟乙唑衍生物CM对L7712细胞膜通透性的影响,探讨了CM辐射增敏作用的可能机理。结果表明:有氧条件下单独照射40Gy以上剂量的γ线,可使细胞膜通透性增加;1mg/ml的CM可明显增加细胞膜的通透性,这两种损伤作用有叠加现象。在0～80Gy剂量范围内,未能观察到CM对受照细胞膜通透性增加有敏化作用。
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| 关 键 词： | 辐射增敏剂 甲硝羟乙唑衍生物 细胞膜通透性 Na_2 ~(51)CrO~4掺入 L_(7712)细胞 |
EFFECTS OF METRONSDAZOLE DERIVATIVE ON MEMBRANE PERMEABILITY OF~51Cr LABELLED L_7712 CELLS |
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| Meng Xiangshun,et al.EFFECTS OF METRONSDAZOLE DERIVATIVE ON MEMBRANE PERMEABILITY OF~51Cr LABELLED L_7712 CELLS[J].Academic Journal of Second Military Medical University,1988(5). |
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| Authors: | Meng Xiangshun |
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| Affiliation: | Division of Radiation Medicine |
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| Abstract: | This report describes the effects of a new radiosensitizer, metronidazole derivative (CM) synthesized in our laboratory, on membrane permeability of 51Cr labelled L7712 cells.It was found that CM could be incorporated into the cancer cells easily, and resulted in increased membrane permeability.Under aerobic condition, the release rate of 51Cr was increased when the cells were irradiated with more than 40 Gy Y-rays.At a dose of 0-80 Gy, the sensitization effects of CM on membrane permeability of irradiated cells were not found. |
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| Keywords: | radiosensitizer metronidazole derivative membrane permeability 51Cr incorporation L7712 cells |
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