| 乳腺癌 nm23-H_1 蛋白表达的研究 |
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| 引用本文： | 姜惠峰,姜颖君,孙桂青,王振,王增慧.乳腺癌 nm23-H_1 蛋白表达的研究[J].中华肿瘤防治杂志,1997(2). |
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| 作者姓名： | 姜惠峰 姜颖君 孙桂青 王振 王增慧 |
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| 作者单位： | 山东省烟台市莱阳中心医院 |
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| 摘 要： | 应用ＳＰ免疫组化法检测８４例乳腺浸润性导管癌中ｎｍ２３－Ｈ１蛋白的表达，结果显示ｎｍ２３－Ｈ１蛋白在７２例（８７．５％）有表达。研究表明ｎｍ２３－Ｈ１蛋白的表达水平与淋巴结转移呈负相关（Ｐ＜０．０１），与ＥＲ、ＰＲ水平呈正相关（Ｐ＜０．０１，Ｐ＜０．０５），而与组织学分级ＰＣＮＡ指数及ＭＤＲ１－Ｐｇｐ的表达无关（Ｐ＞０．０５）。
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| 关 键 词： | 乳腺癌 nm23－H_1 蛋白 免疫组织化学 |
Expression of nm23 H 1 protein in breast carcinoma a nd its correlation with prognostic factors |
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| Jiang Huifeng,Jiang Yingjun,Sun Guiqing,et al..Expression of nm23 H 1 protein in breast carcinoma a nd its correlation with prognostic factors[J].Chinese Journal of Cancer Prevention and Treatment,1997(2). |
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| Authors: | Jiang Huifeng Jiang Yingjun Sun Guiqing |
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| Abstract: | The expression of nm23 H 1 protein in 84 cases breast infiltrating ductal carcinoma was detected by S P immun ohistochemical technique.We found that the expression of nm23 H 1 protein levels in breast carcinoma was inversely associated with metastatic potential(P<0 01).The results showed the nm23 H 1 protein expression in seventy two(85.7%)cases breast carcinoma was positive; it was directly correlated to estrogen recepror (ER)and progesterone receptor(PR)(P<0.01 and P<0.05 respectively),but it was not associated with histological grades,proliferating cell neuclear antigen(PCAN) index, or MDR1 Pgp expression(P>0.05). |
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| Keywords: | Breast neoplasm NM23 H 1 prottein Immunohistochem istry |
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