人乳头状瘤病毒及p53与宫颈癌预后的关系

宫颈癌是妇科常见的恶性肿瘤,世界上每年约500 000女性发病,而75%～80%在发展中国家,居世界第一位,目前其死亡率仍居世界首位,每年约300 000妇女死于此病,严重危害着女性的生命与健康,其发生、发展及预后受到诸多因素的影响.人乳头状瘤病毒感染是宫颈癌发生的主要致病原因,其中以高危型HPV16及18型最常见.p53基因是一种抑癌基因,在许多恶性肿瘤中异常表达,但研究发现宫颈癌中p53功能的缺失却少见.该文将综述人乳头状瘤病毒、p53和宫颈癌预后的相关研究.

Correlation between HPV,p53 and prognosis of cervical carcinoma

Cervical carcinoma is one of the most common female malignant tumors,more than 500 000 cases of cervical carcinoma occur each year all over the world and 75%~80% of the patients are in the developing countries.It remains the second leading cause of death in women worldwide,and about 300 000 women die of this disease each year.Many factors involve in occurrence,development and prognosis of the disease.Human papillomavirus(HPV) infection is a main cause of cervical carcinoma.Among HPV types,the most common ones are HPV 16 and 18.The tumor suppressor gene p53 is expressed abnormally in varied types of human malignant tumors.However,the researchers found that in cervical carcinoma functional deletion of the gene is not common.In this review,we summarized the relevant researches on correlation between HPV,p53 and prognosis of cervical carcinoma.