建立中药复方用半仿生提取研究的技术平台

半仿生提取法(SBE法)是针对中药药效物质提取中存在的“唯成分论”和“通则论”,采用“灰思维方式”将整体药物研究法与分子药物研究法相结合,从生物药剂学的角度为经消化道给药的中药制剂创立的一种提取新技术。经对多种中药及其复方的研究,结果皆提示：半仿生提取法有可能替代(WE法水提取法);(SBAE法半仿生提取醇沉淀法)有可能替代(WAE法水提醇沉淀法)。本文以黄连解毒汤和慈航丹为例,对建立中药复方半仿生提取研究的技术平台作了介绍。

Establishment of A Platform for Study of Compound Dncgs of Chinese Medicine by Method of Semibionic Extraction

The method of semi - bionic extraction (SBE) is a new technology of extraction, which is created, by the way of " gray thinking" to combine the method of study on the wholism of drugs with the method of study on the molecules of drugs and in view of existing " the theory of unique importance of medicinal components" and " the theory of general rules", especially for the preparations of Chinese medicine teken through digestive tract as considered from the viewpoint of bio - pharmaceutics. The result of study on quite a lot of Chinese drugs and their compounds shows that the SBE method may replace the method of water extraction (WE) and the method of semi - bionic alcohol extraction (SBAE) may replace the method of water alcohol extraction (WAE). Taking Huangliangjiedutang (Panax Notoginseng Detoxicating Liquid) and Cihangdan Pill for examples, this article describes the establishment of the technical platform for the study of the semi - bionic extraction of the compounds of Chinese drugs.