乳腺良恶性病变肥大细胞反应的研究

目的探讨肥大细胞在乳腺良恶性病变组织中的分布和数量并探讨其意义。方法应用甲苯胺蓝法检测40例乳腺癌,45例正常及良性病变中肥大细胞的表达。结果良性病变中肥大细胞数量(3.8±0.37)明显高于正常乳腺组织(0.62±0.18)。乳腺癌组织周边部肥大细胞计数(2.40±0.28)高于癌组织内部(1.36±0.17),二者比较,有显著性差异(P<0.01)。乳腺癌有淋巴结转移的肥大细胞数量(3.14±0.39)明显高于乳腺癌没有淋巴结转移的肥大细胞数量(1.96±0.36),两者有显著性差异。结论间质肥大细胞反应作为宿主的防御系统之一,在维持机体自身稳定过程中起着重要的作用。间质肥大细胞反应可能是判断乳腺癌预后的重要指标。

The investigation of mast cell response in benign and malignant breast lesions

Objective To investigate the number and distribution of mast cell in benign and malignant breast lesions and investigate the significance.Methods The expression of mast cell was observed by toluidne blue stain in 40 breast cancer and 45 benign breast lesions.Results The number of mast cell in benign breast lesions(3.8±0.37) was higher than that of normal breast tissue,and there was a statistical significance(P<0.05).The number of mast cell in the surrounding of breast cancer(2.40±0.28) was higher than that in the center of breast cancer(1.36±0.17) and there was a statistical significance(P<0.01).The number of mast cell in breast cancer patients with regional lymph node metastasis was higher than that without regional lymph node metastasis(P<0.05).Conclusion Mast cell response is one of defentive systems of human being,it is very useful to keep stabilization of human environment.Mast cell response is an important factor to determine the prognosis of breast cancer.