| 白萝卜提取物促胃动力作用中Cajal间质细胞与P物质的变化 |
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| 引用本文： | 黄裕新,王伟,夏德雨,颜云龙,冯国华,王景杰.白萝卜提取物促胃动力作用中Cajal间质细胞与P物质的变化[J].胃肠病学和肝病学杂志,2008,17(6):467-469. |
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| 作者姓名： | 黄裕新 王伟 夏德雨 颜云龙 冯国华 王景杰 |
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| 作者单位： | 第四军医大学唐都医院消化科,陕西,西安,710038 |
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| 摘 要： | 目的探讨白萝卜提取物（raphanus sativus 1 extract，Ecr）通过Cajal间质细胞促胃肠动力作用机制。方法40只SD大鼠随机分为A（Ecr）组、B（0．9％氯化钠对照）组分别灌服等体积Ecr和0．9％氯化钠，1h后用双重免疫荧光组织化学标记的方法观察胃电起搏区Cajal间质细胞（interstitial cells of Cajal，ICC）与P物质（SP）阳性神经及产物表达的变化。结果肌间神经丛中ICC与SP阳性神经呈网络样分布，二者紧密毗邻；肌间神经丛及肌层内与ICC结合的SP阳性神经产物表达明显增加（P〈0．01）。结论白萝卜提取物的促胃肠动力作用可能与胃体ICC上结合的SP阳性神经产物表达增高有密切关系。
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| 关 键 词： | 白萝卜提取物 CAJAL间质细胞 P物质 双重免疫荧光组织化学 |
| 文章编号： | 1006-5709(2008)06-0467-03 |
| 修稿时间： | 2007年12月21 |
Kinetogenic effects of raphanus sativus I extract on Cajal and SP changes in gastrointestinal tract |
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| HUANG Yuxin,WANG Wei,XIA Deyu,YAN Yunlong,FENG Guohua,WANG Jingjie.Kinetogenic effects of raphanus sativus I extract on Cajal and SP changes in gastrointestinal tract[J].Chinese Journal of Gastroenterology and Hepatology,2008,17(6):467-469. |
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| Authors: | HUANG Yuxin WANG Wei XIA Deyu YAN Yunlong FENG Guohua WANG Jingjie |
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| Affiliation: | HUANG Yuxin,WANG Wei, XIA Deyu,YAN Yunlong, FENG Guohua, WANG Jingjie (Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi＇ an 710038, China) |
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| Abstract: | Objective To study the mechanisms of Raphanus sativus 1 extract（Ecr）. Methods Forty SD rats were randomly divided into A（Ecr） group and B（control）group. Ecr or 0.9% Nacl were given respectively. The distributions of SP and Cajal in gastric body investigated by double immunofluorescin histochemistry method 1 h later. Results The expressions of SP on Cajal increased significantly （P〈0.01 ） in gastric body of rats at 1 h after Ecr given. Conclusion The kinetogenic effect of Ecr is closely correlated to the increase of SP on Cajal expression. |
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| Keywords: | Ecr ICC SP Double immunofluorescin histochemistry |
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