小牛血清去蛋白注射液联合丁苯酞治疗急性缺血性脑梗死的临床研究

目的观察小牛血清去蛋白注射液联合丁苯酞治疗急性缺血性脑梗死的临床效果。方法选取2013年5月—2015年5月唐山康复医疗中心收治的急性缺血性脑梗死患者250例,随机分为对照组和治疗组,每组各125例。对照组静脉滴注丁苯酞氯化钠注射液,100 mL/次,2次/d,每次静脉滴注时间大于50 min。治疗组在对照组治疗基础上静脉滴注小牛血清去蛋白注射液,20 mL溶于生理盐水250 mL,1次/d。两组均连续治疗14 d。观察两组的临床疗效,同时比较两组治疗前后临床神经功能缺损程度(NDS)评分、超氧化物歧化酶(SOD)活性和丙二醛(MDA)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为69.6%、86.4%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者NDS评分、MDA均显著降低,SOD显著升高,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论小牛血清去蛋白注射液联合丁苯酞治疗急性缺血性脑梗死临床疗效较好,能够改善患者神经功能缺损,安全性好,具有一定的临床推广应用价值。

Clinical study on Deproteinised Calf Blood Serum Injection combined with butylphthalide in treatment of acute ischemic cerebral infarction

tients (88 cases) with endometrial carcinoma in the Lingao People''s Hospital from April 2013 to August 2015 were divided into control and treatment group according to different treatment plans, and each group had 44 cases. All patients were given necessary basic treatment. The patients in the control group were po administered with Megestrol Acetate Tablets, 160 mg/time, once daily. The patients in the treatment group were iv administered with Compound Kushen Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 4 weeks. After treatment, short-term efficacies between two groups were compared, equally, the improvement of survival quality and adverse reactions were evaluated. Results After treatment, ORR and CBR in the control group were respectively 43.18% and 70.45%, equally, ORR and CBR in the treatment group were 65.91% and 88.64%, and there were differences between two groups (P < 0.05). After treatment, the improvement rate of survival quality in the control and treatment groups were 75.00% and 90.91%, respectively, and there were differences between two groups (P < 0.05). During the treatment, cases of adverse reactions in the control group were more than those in the treatment group, and the difference was statistically significant (P < 0.05). Conclusion Compound Kushen Injection combined with megestrol acetate has a good clinical efficacy in the treatment of endometrial carcinoma, and there are more adverse reactions in the control group than those in the treatment group, also can significantly improve the life quality, which has a certain clinical application value.